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Title

Induction of thymocytotoxic autoantibodies after injection of bacterial lipopolysaccharides in mice
Authors
Izui, Shozo
Kobayakawa, T.
Louis, Jacques
Lambert, Paul Henri
Published in European Journal of Immunology. 1979, vol. 9, no. 4, p. 338-341
Abstract The injection of bacterial lipopolysaccharides (Salmonella typhimurium and Escherichia coli LPS) has been shown to induce thymocytotoxic autoantibodies in various strains of mice (C57BL/6, BALB/c, DBA/2, AKR, A/J and C3HeB/FeJ). Titers up to l:16 were observed. Such antibodies did not develop in C3H/HeJ mice which are low responders to LPS. The thymocytotoxic antibodies had the following characteristics: (a) 2-mercaptoethanol sensitivity, (b) optimal reactivity at 4 degrees C, (c) cytotoxicity for autologous and syngeneic thymocytes but not for spleen cells. The cytotoxicity decreased after absorption with thymocytes, spleen cells or brain tissue but not with kidney or liver homogenates. These LPS-induced thymocytotoxic antibodies were similar to the natural thymocytotoxic antibody occurring in NZB mice.
Keywords Animals — Antibody Formation — Autoantibodies/ immunology — Cytotoxicity, Immunologic — Escherichia coli — Injections, Intraperitoneal — Lipopolysaccharides/ administration & dosage — Mice — Mice, Inbred AKR — Mice, Inbred BALB C — Mice, Inbred C3H — Mice, Inbred C57BL — Mice, Inbred DBA — Mice, Inbred NZB — Salmonella typhimurium — T-Lymphocytes/ immunology
Identifiers
PMID: 381011
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Structures
Faculté de médecine / Section de médecine fondamentale / Département de pathologie et immunologie
Citation
(ISO format) 		IZUI, Shozo et al. Induction of thymocytotoxic autoantibodies after injection of bacterial lipopolysaccharides in mice. In: European Journal of Immunology, 1979, vol. 9, n° 4, p. 338-341. doi: 10.1002/eji.1830090416 https://archive-ouverte.unige.ch/unige:10922

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Deposited on : 2010-08-26

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