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Scientific article
English

Surface proteins of radiation-induced and radiation leukemia virus-induced thymic lymphosarcomas in mice

Published inLeukemia research, vol. 7, no. 2, p. 205-219
Publication date1983
Abstract

Thymic lymphosarcomas (TLS) were induced in C57BL mice by X-rays or by Radiation Leukemia Virus (RadLV) and their surface glycoproteins (gps) compared after cell-surface radioiodination and polyacrylamide gel electrophoresis (SDS-PAGE). All lymphocytic antigens tested (T200, 170/100, Thy-1) and proteins with apparent molecular weight (Mr) around 120,000 and 100,000 were present on all tumours, as well as retrovirus--encoded proteins but considerable variation in the Mr of several serologically-related proteins was observed. Therefore, the TLS in C57BL mice form a heterogeneous group, suggesting that T cells can be transformed at different stages of maturation. The possibility that transformation allows or even triggers differentiation is also entertained.

Keywords
  • Animals
  • Antigens, Surface/analysis
  • Antigens, Thy-1
  • Autoradiography
  • Electrophoresis, Polyacrylamide Gel
  • Female
  • Glycoproteins/analysis
  • Lymphoma, Non-Hodgkin/etiology/ metabolism
  • Mice
  • Mice, Inbred C57BL
  • Neoplasm Proteins/ analysis
  • Neoplasms, Experimental/etiology/metabolism
  • Neoplasms, Radiation-Induced/ metabolism
  • T-Lymphocytes
  • Tumor Virus Infections/ metabolism
  • Viral Proteins/analysis
Affiliation Not a UNIGE publication
Citation (ISO format)
HOOGHE, R., HOESSLI, Daniel, JANOWSKI, M. Surface proteins of radiation-induced and radiation leukemia virus-induced thymic lymphosarcomas in mice. In: Leukemia research, 1983, vol. 7, n° 2, p. 205–219.
Identifiers
ISSN of the journal0145-2126
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