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Lack of association of V beta 8+ T cells with lupus-like syndrome in MRL-lpr/lpr mice

Fossati-Jimack, Liliane
Merino, Ramon
Iwamoto, Masahiro
Published in European Journal of Immunology. 1994, vol. 24, no. 7, p. 1717-1720
Abstract To evaluate the role of V beta 8+ T cells in the development of lupus-like autoimmune syndrome in MRL-lpr/lpr mice, we treated them with the F23.1 anti-V beta 8 monoclonal antibody (mAb) from birth to 4 months of age. Here we report that almost complete depletion of V beta 8+ T cells by the F23.1 mAb treatment neither inhibited nor delayed the development of hypergammaglobulinemia, autoantibody production and autoimmune glomerulonephritis in MRL-lpr/lpr mice. In addition, the F23.1 mAb treatment did not prevent the development of lymphadenopathy and the generation of a CD4-CD8- double-negative T cell subset, characteristically accumulating in lpr lymph nodes. Our results strongly argue against the idea that the V beta 8+ T cells play a critical role in the development of lupus-like autoimmune syndrome in MRL-lpr/lpr mice.
Keywords AnimalsAntibodies, Monoclonal/therapeutic useAntigens, Surface/biosynthesisDisease Models, AnimalFlow CytometryLupus Erythematosus, Systemic/ immunology/prevention & controlLymphatic Diseases/ immunology/prevention & controlMiceMice, Mutant StrainsReceptors, Antigen, T-Cell, alpha-beta/ immunology
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PMID: 8026533

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Deposited on : 2010-08-26

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