Lack of association of V beta 8+ T cells with lupus-like syndrome in MRL-lpr/lpr mice
|Published in||European Journal of Immunology. 1994, vol. 24, no. 7, p. 1717-1720|
|Abstract||To evaluate the role of V beta 8+ T cells in the development of lupus-like autoimmune syndrome in MRL-lpr/lpr mice, we treated them with the F23.1 anti-V beta 8 monoclonal antibody (mAb) from birth to 4 months of age. Here we report that almost complete depletion of V beta 8+ T cells by the F23.1 mAb treatment neither inhibited nor delayed the development of hypergammaglobulinemia, autoantibody production and autoimmune glomerulonephritis in MRL-lpr/lpr mice. In addition, the F23.1 mAb treatment did not prevent the development of lymphadenopathy and the generation of a CD4-CD8- double-negative T cell subset, characteristically accumulating in lpr lymph nodes. Our results strongly argue against the idea that the V beta 8+ T cells play a critical role in the development of lupus-like autoimmune syndrome in MRL-lpr/lpr mice.|
|Keywords||Animals — Antibodies, Monoclonal/therapeutic use — Antigens, Surface/biosynthesis — Disease Models, Animal — Flow Cytometry — Lupus Erythematosus, Systemic/ immunology/prevention & control — Lymphatic Diseases/ immunology/prevention & control — Mice — Mice, Mutant Strains — Receptors, Antigen, T-Cell, alpha-beta/ immunology|
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|FOSSATI-JIMACK, Liliane et al. Lack of association of V beta 8+ T cells with lupus-like syndrome in MRL-lpr/lpr mice. In: European Journal of Immunology, 1994, vol. 24, n° 7, p. 1717-1720. https://archive-ouverte.unige.ch/unige:10896|