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Intraplaque Expression of C-Reactive Protein Predicts Cardiovascular Events in Patients with Severe Atherosclerotic Carotid Artery Stenosis

Bonaventura, Aldo
Brandt, Karim J
Pende, Aldo
Bertolotto, Maria
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Published in Mediators of Inflammation. 2016, vol. 2016, p. 9153673
Abstract Serum c-reactive protein (CRP) was suggested for the assessment of intermediate cardiovascular (CV) risk. Here, systemic or intraplaque CRP levels were investigated as predictors of major adverse cardiovascular events (MACEs) in patients with severe carotid stenosis. CRP levels were assessed in the serum and within different portions (upstream and downstream) of carotid plaques of 217 patients undergoing endarterectomy. The association between CRP and intraplaque lipids, collagen, neutrophils, smooth muscle cells (SMC), and macrophage subsets was determined. No correlation between serum CRP and intraplaque biomarkers was observed. In upstream portions, CRP content was directly correlated with intraplaque neutrophils, total macrophages, and M1 macrophages and inversely correlated with SMC content. In downstream portions, intraplaque CRP correlated with M1 and M2 macrophages. According to the cut-off point (CRP > 2.9%) identified by ROC analysis in upstream portions, Kaplan-Meier analysis showed that patients with high CRP levels had a greater rate of MACEs. This risk of MACEs increased independently of age, male gender, serum CRP, and statin use. In conclusion, in patients with severe carotid artery stenosis, high CRP levels within upstream portions of carotid plaques directly and positively correlate with intraplaque inflammatory cells and predict MACEs at an 18-month follow-up period.
Keywords Age FactorsAgedBiomarkers/blood/metabolismC-Reactive Protein/metabolismCarotid Stenosis/blood/metabolismFemaleHumansKaplan-Meier EstimateMacrophages/metabolismMaleMyocytes, Smooth Muscle/metabolismNeutrophils/metabolismROC CurveRisk FactorsSex Factors
PMID: 27738391
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Research groups Chimie et protéomique clinique (270)
Traits génétiques complexes (901)
L'athérosclérose et ses complications cliniques (591)
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BONAVENTURA, Aldo et al. Intraplaque Expression of C-Reactive Protein Predicts Cardiovascular Events in Patients with Severe Atherosclerotic Carotid Artery Stenosis. In: Mediators of Inflammation, 2016, vol. 2016, p. 9153673. doi: 10.1155/2016/9153673 https://archive-ouverte.unige.ch/unige:108830

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Deposited on : 2018-10-03

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