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Title

The Associations of Blood Kidney Injury Molecule-1 and Neutrophil Gelatinase-Associated Lipocalin with Progression from CKD to ESRD.

Authors
Alderson, Helen V
Ritchie, James P
Middleton, Rachel J
Kalra, Philip A
Published in Clinical Journal of the American Society of Nephrology. 2016, vol. 11, no. 12, p. 2141-2149
Abstract Elevated levels of urinary kidney injury molecule-1 and neutrophil gelatinase-associated lipocalin are associated with negative outcomes in CKD. Our study aimed to explore the prognostic accuracy of blood levels of kidney injury molecule-1 and neutrophil gelatinase-associated lipocalin for progression to ESRD, major adverse cardiovascular events, and death in a large cohort of adult patients with all-cause nondialysis-dependent CKD stages 3-5. We considered whether these factors improve prediction in relation to traditional biomarkers and clinical parameters.
Keywords AgedAged, 80 and overBiomarkers/bloodCoronary Disease/surgeryDisease ProgressionFemaleFollow-Up StudiesGlomerular Filtration RateHepatitis A Virus Cellular Receptor 1/bloodHumansKidney Failure, Chronic/blood/physiopathology/therapyLipocalin-2/bloodMaleMiddle AgedMortalityMyocardial Infarction/bloodPrognosisProportional Hazards ModelsProspective StudiesROC CurveRenal Insufficiency, Chronic/bloodRisk FactorsStroke/blood
Identifiers
PMID: 27852662
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Research group Chimie et protéomique clinique (270)
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ALDERSON, Helen V et al. The Associations of Blood Kidney Injury Molecule-1 and Neutrophil Gelatinase-Associated Lipocalin with Progression from CKD to ESRD. In: Clinical Journal of the American Society of Nephrology, 2016, vol. 11, n° 12, p. 2141-2149. https://archive-ouverte.unige.ch/unige:108829

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Deposited on : 2018-10-03

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