en
Scientific article
English

Effect of cyclosporin A and zidovudine on immune abnormalities observed in the murine acquired immunodeficiency syndrome

Published inThe Journal of infectious diseases, vol. 166, no. 2, p. 285-290
Publication date1992
Abstract

Two therapeutic modalities, zidovudine (targeting retroviral replication) and cyclosporin A (targeting immunopathologic consequences of retroviral expression) were evaluated in a murine model of AIDS. In previous studies, cyclosporin A treatment (40 or 60 mg/kg/day) before and after infection with LP-BM5 murine leukemia viruses protected against the development of immunodeficiency disease. The present study extends these findings. First, a low dose of cyclosporin A (20 mg/kg/day) was ineffective, and treatment initiated 5 days after infection did not protect against virus-induced lymphoproliferation and hypergammaglobulinemia. Second, zidovudine added to drinking water (0.1 mg initiated 5 days after infection and continued for 8 weeks) was more effective than 0.2 mg/mL given day 5-12 after infection. This treatment reduced lymph node size, disease severity as determined histologically, retrovirus-induced gp70 expression, and IgE (but not IgM and IgG) levels. Third, combined treatment had an additive, protective effect on lymphocyte proliferative capacity. This successful dual therapeutic strategy in a mouse model has potential applicability for similar approaches in treating human immunodeficiency virus infection.

Keywords
  • Animals
  • Cyclosporine/pharmacology/ therapeutic use
  • Dose-Response Relationship, Drug
  • Drug Therapy, Combination
  • Female
  • Hypergammaglobulinemia/drug therapy
  • Lymph Nodes/pathology
  • Lymphocyte Activation/drug effects
  • Mice
  • Mice, Inbred C57BL
  • Murine Acquired Immunodeficiency Syndrome/ drug therapy/immunology
  • Retroviridae Proteins, Oncogenic/blood
  • Viral Envelope Proteins/blood
  • Zidovudine/pharmacology/ therapeutic use
Affiliation Not a UNIGE publication
Citation (ISO format)
CERNY, A. et al. Effect of cyclosporin A and zidovudine on immune abnormalities observed in the murine acquired immunodeficiency syndrome. In: The Journal of infectious diseases, 1992, vol. 166, n° 2, p. 285–290. doi: 10.1093/infdis/166.2.285
Identifiers
ISSN of the journal0022-1899
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