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Recent trends in prostate cancer mortality show a continuous decrease in several countries

Rapin, Charles Henry
Schmidlin, France
Published in International journal of cancer. 2008, vol. 123, no. 2, p. 421-429
Abstract Prostate specific antigen (PSA) screening was introduced to detect prostate cancer at an early stage and to reduce prostate cancer-specific mortality. Until results from clinical trials are available, the efficacy of PSA screening in reducing prostate cancer mortality can be estimated by surveillance of prostate cancer mortality trends. Our study analyzes recent trends in prostate cancer mortality in 38 countries. We used the IARC-WHO cancer mortality database and performed joinpoint analysis to examine prostate cancer mortality trends and identified 3 patterns. In USA, and to a lesser extent in Germany, Switzerland, Canada, France, Italy and Spain, prostate cancer-specific mortality decreased to a level lower than before the introduction of PSA screening. In Australia, New Zealand, Austria, Finland, The Netherlands, Norway, United Kingdom, Hungary, Slovakia, Israel, Singapore, Sweden and Portugal, mortality from prostate cancer decreased but rates remain higher than before the introduction of PSA screening. Prostate cancer mortality continued to increase in Belgium, Denmark, Greece, Ireland, Bulgaria, Czech Republic, Belarus, Ukraine, Russian Federation, Romania, Poland, Argentina, Chile, Cuba, Mexico, Japan, China Hong Kong and the Republic of Korea. The trends in prostate cancer mortality rates in examined countries suggest that PSA screening may be effective in reducing mortality from prostate cancer.
Keywords AgedAmericas/epidemiologyAustralia/epidemiologyEurope/epidemiologyHumansMaleMass Screening/methodsMiddle AgedMortality/trendsProstate-Specific Antigen/bloodProstatic Neoplasms/diagnosis/immunology/mortality
PMID: 18452171
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Article (Accepted version) (503 Kb) - document accessible for UNIGE members only Limited access to UNIGE
Research groups Epidémiologie des tumeurs (1017)
Groupe Bouchardy Magnin Christine (Registre genevois des tumeurs) (532)
Groupe Miralbell Raymond (radio-oncologie) (685)
(ISO format)
BOUCHARDY MAGNIN, Christine et al. Recent trends in prostate cancer mortality show a continuous decrease in several countries. In: International journal of cancer, 2008, vol. 123, n° 2, p. 421-429. doi: 10.1002/ijc.23520 https://archive-ouverte.unige.ch/unige:1084

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Deposited on : 2009-03-05

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