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An antifungal naphthoquinone, xanthones and secoiridoids from Swertia calycina

Rodriguez, S
Hakizamungu, E
Hostettmann, K
Published in Planta Medica. 1995, vol. 61, no. 4, p. 362-364
Abstract A chemical and biological screening of 25 species of the Gentianaceae family has been undertaken. Both methanolic and dichloromethane extracts of Swertia calycina exhibited a strong antifungal activity against Cladosporium cucumerinum and Candida albicans. The compound responsible for this activity has been isolated and identified as 2-methoxy-1,4-naphthoquinone. It is the first naphthoquinone to be described in Gentianaceae species. LC-UV and LC-TSP-MS analysis of the crude extracts of Swertia calycina also allowed on-line identification of six known xanthones and secoiridoids.
Keywords Antifungal Agents/isolation & purification/pharmacologyChromatography, High Pressure LiquidGlucosides/isolation & purification/pharmacologyIridoid GlucosidesIridoidsMass SpectrometryMicrobial Sensitivity TestsNaphthoquinones/isolation & purification/pharmacologyPlant ExtractsPyrans/isolation & purification/pharmacologyRwanda
PMID: 7480185
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RODRIGUEZ, S et al. An antifungal naphthoquinone, xanthones and secoiridoids from Swertia calycina. In: Planta Medica, 1995, vol. 61, n° 4, p. 362-364. doi: 10.1055/s-2006-958102

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