Scientific Article
previous document  unige:108157  next document
add to browser collection
Title

Antifungal and antibacterial naphthoquinones from Newbouldia laevis roots

Authors
Gafner, S
Nianga, M
Stoeckli-Evans, H
Hostettmann, K
Published in Phytochemistry. 1996, vol. 42, no. 5, p. 1315-1320
Abstract From a dichloromethane extract of Newbouldia laevis roots, four new (6-hydroxydehydroiso-alpha-lapachone, 7-hydroxydehydroiso-alpha-lapachone, 5,7-dihydroxydehydroiso-alpha-lapachone and 3-hydroxy-5-methoxydehydroiso-alpha-lapachone) and six known naphthoquinones have been isolated. Their structures were established by spectroscopic methods (UV, EI mass spectrometry, 1H and 13C NMR) and that of 7-hydroxydehydroiso-alpha-lapachone was confirmed by X-ray crystallography. All naphthoquinones showed antifungal activity against Cladosporium cucumerinum and Candida albicans, and activity against the bacteria Bacillus subtilis and Escherichia coli.
Keywords Anti-Bacterial Agents/chemistry/isolation & purificationAntifungal Agents/chemistry/isolation & purificationCrystallography, X-RayNaphthoquinones/chemistry/isolation & purificationPlants, Medicinal/chemistrySpectrum Analysis
Identifiers
PMID: 9397206
Full text
Article (Published version) (470 Kb) - document accessible for UNIGE members only Limited access to UNIGE
Citation
(ISO format)
GAFNER, S et al. Antifungal and antibacterial naphthoquinones from Newbouldia laevis roots. In: Phytochemistry, 1996, vol. 42, n° 5, p. 1315-1320. https://archive-ouverte.unige.ch/unige:108157

9 hits

0 download

Update

Deposited on : 2018-09-21

Export document
Format :
Citation style :