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Antifungal and antibacterial naphthoquinones from Newbouldia laevis roots

Gafner, S
Nianga, M
Stoeckli-Evans, H
Hostettmann, K
Published in Phytochemistry. 1996, vol. 42, no. 5, p. 1315-1320
Abstract From a dichloromethane extract of Newbouldia laevis roots, four new (6-hydroxydehydroiso-alpha-lapachone, 7-hydroxydehydroiso-alpha-lapachone, 5,7-dihydroxydehydroiso-alpha-lapachone and 3-hydroxy-5-methoxydehydroiso-alpha-lapachone) and six known naphthoquinones have been isolated. Their structures were established by spectroscopic methods (UV, EI mass spectrometry, 1H and 13C NMR) and that of 7-hydroxydehydroiso-alpha-lapachone was confirmed by X-ray crystallography. All naphthoquinones showed antifungal activity against Cladosporium cucumerinum and Candida albicans, and activity against the bacteria Bacillus subtilis and Escherichia coli.
Keywords Anti-Bacterial Agents/chemistry/isolation & purificationAntifungal Agents/chemistry/isolation & purificationCrystallography, X-RayNaphthoquinones/chemistry/isolation & purificationPlants, Medicinal/chemistrySpectrum Analysis
PMID: 9397206
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GAFNER, S et al. Antifungal and antibacterial naphthoquinones from Newbouldia laevis roots. In: Phytochemistry, 1996, vol. 42, n° 5, p. 1315-1320.

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Deposited on : 2018-09-21

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