On-Demand Degradation of Metal–Organic Framework Based on Photocleavable Dianthracene-Based Ligand

Collet, Guillaume; Lathion, Timothee; Besnard, Céline; Piguet, Claude; Petoud, Stéphane

doi:10.1021/jacs.8b05047

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Title		On-Demand Degradation of Metal–Organic Framework Based on Photocleavable Dianthracene-Based Ligand
Authors		Collet, Guillaume Lathion, Timothee Besnard, Céline Piguet, Claude Petoud, Stéphane
Published in		Journal of the American Chemical Society. 2018, vol. 140, no. 34, p. 10820-10828
Abstract		We have designed a rigid photocleavable dianthracene-based ligand that reacts with ytterbium as coordination metal ion for the creation of a class of tridimensional light-degradable metal−organic framework (MOF). We demonstrated that we can obtain a high level of control on the disassembly of the MOF formed with this ligand which can be triggered either through light irradiation or temperature increase. The reversible 4π-4π photodimerization is the intrinsic chemical mechanism ruling the ligand and MOF cleavage. In the fields of biology and medicine, MOFs have sparked a strong interest as highly porous vehicles for drug release but have only been explored so far through the passive leakage of their payloads. The designed light-degradable MOFs can potentially overcome this limitation and serve as prototypes for drug delivery and corresponding therapeutic applications.
Identifiers		DOI: 10.1021/jacs.8b05047
Full text		Article (Published version) (4.1 MB) - Limited access to UNIGE Article (Accepted version) (776 Kb) - Free access
Structures		Faculté des sciences / Section de chimie et biochimie / Département de chimie minérale, analytique et appliquée
Research group		Groupe Piguet
Citation (ISO format)		COLLET, Guillaume et al. On-Demand Degradation of Metal–Organic Framework Based on Photocleavable Dianthracene-Based Ligand. In: Journal of the American Chemical Society, 2018, vol. 140, n° 34, p. 10820-10828. doi: 10.1021/jacs.8b05047 https://archive-ouverte.unige.ch/unige:108077