Given the lack of general consensus in the literature regarding the best method to rehabilitate partially edentulous patients with extended atrophic edentulous sites in the posterior zone of the mandible, and with a residual ridge height less than 8 mm (with or without bone augmentation procedures), the aim of this systematic review was to analyze all the relevant randomized clinical trials (RCT), and, by means of a meta-analysis of the collected data, draw some conclusions regarding the best available treatments for the rehabilitation of posterior edentulism in partially dentate mandible.