Scientific article

Imaging the porous structure in the core of degrading PLGA microparticles: The effect of molecular weight

Published inJournal of Controlled Release, vol. 286, p. 231-239
Publication date2018

The aim of this study was to understand the pore formation mechanisms of degrading poly(d,l-lactic-co-glycolic acid) (PLGA) microparticulate systems. This was investigated through an original microparticles cross-section imaging method. Atorvastatin (ATV)-loaded 16- to 18-μm spherical microparticles with polymers of varying molecular weights (8 to 45 kDa) were prepared. The evolution of the particles during in vitro drug release experiments was monitored in terms of molecular weight, pore formation and glass transition temperature. During the 2nd phase of release, two types of pores were observed: small pores near the particle's periphery and larger pores in the core. The pattern of pore formation was shown to be related to the shape of the drug release curve. At the onset of the 3rd phase, the polymer transitions to a less glassy state, allowing for the swelling of the microparticles. Overall, we present evidence that pore formation is not uniformly distributed throughout PLGA microparticles, and that it could determine the drug release kinetics.

  • PLGA microparticles
  • Pores
  • Molecular weight
  • Erosion
  • Swelling
  • Drug release mechanism
  • Atorvastatin
Citation (ISO format)
MYLONAKI, Ioanna et al. Imaging the porous structure in the core of degrading PLGA microparticles: The effect of molecular weight. In: Journal of Controlled Release, 2018, vol. 286, p. 231–239. doi: 10.1016/j.jconrel.2018.07.044
Main files (1)
Article (Published version)
ISSN of the journal0168-3659

Technical informations

Creation08/08/2018 11:42:00 AM
First validation08/08/2018 11:42:00 AM
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