fr
Article scientifique
Accès libre
Anglais

Oxidized lipids keep heat shock chaperones busy: new insights on the deficiencies of tumour-associated dendritic cells

Contributeurs/tricesNunes-Hasler, Paulaorcid
Publié dansJournal for ImmunoTherapy of Cancer, vol. 6, no. 60, 3
Date de publication2018
Résumé

In a recent publication in Nature Communications the group of Dr. Dmitry Gabrilovich takes us one step closer to understanding why lipid accumulation impairs the function of tumour-associated dendritic cells (DCs). In this study, the authors present two surprising and significant findings. First, they show that in mouse DCs oxidized lipids function as a sink that traps the heat shock chaperone HSP70, a molecular target of emerging anti-cancer strategies. Secondly, they find that HSP70 in turn regulates the trafficking of peptide-loaded major histocompatibility complex class I (pMHC-I) molecules, a complex that triggers the proliferation of cancer-killing T cells. These observations are discussed briefly in the context of lipid droplet function and pMHC-I trafficking in tumour-associated DCs, as well as HSP70's pleiotropic and incompletely understood roles - and what they mean for future cancer therapy designs.

Mots-clés
  • Heat-shock protein
  • Hspa1a
  • Hsp72m
  • Lipid bodies
  • Antigen presentation
  • Cross-presentation
Citation (format ISO)
NUNES-HASLER, Paula. Oxidized lipids keep heat shock chaperones busy: new insights on the deficiencies of tumour-associated dendritic cells. In: Journal for ImmunoTherapy of Cancer, 2018, vol. 6, n° 60, p. 3. doi: 10.1186/s40425-018-0373-3
Fichiers principaux (1)
Article (Published version)
Identifiants
ISSN du journal2051-1426
370vues
140téléchargements

Informations techniques

Création07/08/2018 10:43:00
Première validation07/08/2018 10:43:00
Heure de mise à jour15/03/2023 08:38:41
Changement de statut15/03/2023 08:38:40
Dernière indexation12/02/2024 11:34:48
All rights reserved by Archive ouverte UNIGE and the University of GenevaunigeBlack