Scientific article
Open access

Sumoylation of Drosophila SU(VAR)3-7 is required for its heterochromatic function

Published inNucleic acids research, vol. 38, no. 13, p. 4254-4262
Publication date2010

In Drosophila, SU(VAR)3-7 is an essential heterochromatin component. It is required for proper chromatin condensation, and changing its dose modifies position-effect variegation. Sumoylation is a post-translational modification shown to play a role in diverse biological processes. Here, we demonstrate that sumoylation is essential for proper heterochromatin function in Drosophila through modification of SU(VAR)3-7. Indeed, SU(VAR)3-7 is sumoylated at lysine K839; this modification is required for localization of SU(VAR)3-7 at pericentric heterochromatin, chromosome 4, and telomeres. In addition, sumoylation of SU(VAR)3-7 is a prerequisite for its ability to enhance position-effect variegation. Thus, these results show that the heterochromatic function of SU(VAR)3-7 depends on its own sumoylation, and unveil a role for sumoylation in Drosophila heterochromatin.

  • HP1 chromo domain
  • Histone H3
  • Sumo modification
  • Lysine 9
  • Protein
  • Gene
  • Modifier
  • Melanogaster
  • Methylation
Citation (ISO format)
REO, Emanuela et al. Sumoylation of Drosophila SU(VAR)3-7 is required for its heterochromatic function. In: Nucleic acids research, 2010, vol. 38, n° 13, p. 4254–4262. doi: 10.1093/nar/gkq168
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Article (Published version)
ISSN of the journal0305-1048

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