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Title

A bosentan pharmacokinetic study to investigate dosing regimens in paediatric patients with pulmonary arterial hypertension: FUTURE-3

Authors
Berger, Rolf M F
Gehin, Martine
Ivy, Dunbar
Kusic-Pajic, Andjela
Cornelisse, Peter
Grill, Simon
Bonnet, Damien
Published in British Journal of Clinical Pharmacology. 2017, vol. 83, no. 8, p. 1734-1744
Abstract The aim of the present study was to investigate whether increasing the bosentan dosing frequency from 2 mg kg-1 twice daily (b.i.d.) to 2 mg kg-1 three times daily (t.i.d.) in children with pulmonary arterial hypertension (PAH) (from ≥3 months to <12 years of age) would increase exposure.
Keywords AdministrationOralAntihypertensive Agents/pharmacokinetics/therapeutic useArea Under CurveChildChildPreschoolDose-Response RelationshipDrugDrug Administration ScheduleEndothelin Receptor Antagonists/pharmacokinetics/therapeutic useFemaleHumansHypertensionPulmonary/drug therapyInfantMaleProspective StudiesSulfonamides/pharmacokinetics/therapeutic use
Identifiers
PMID: 28213957
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Article (Published version) (635 Kb) - public document Free access
Structures
Research group L'hypertension pulmonaire (pédiatrie) (228)
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(ISO format)
BERGER, Rolf M F et al. A bosentan pharmacokinetic study to investigate dosing regimens in paediatric patients with pulmonary arterial hypertension: FUTURE-3. In: British Journal of Clinical Pharmacology, 2017, vol. 83, n° 8, p. 1734-1744. https://archive-ouverte.unige.ch/unige:107597

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Deposited on : 2018-09-11

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