Pediatric Development of Bosentan Facilitated by Modeling and Simulation

Zisowsky, Jochen; Géhin, Martine; Kusic-Pajic, Andjela; Krause, Andreas; Beghetti, Maurice; Dingemanse, Jasper

doi:10.1007/s40272-016-0206-0

Scientific article

English

Pediatric Development of Bosentan Facilitated by Modeling and Simulation

ContributorsZisowsky, Jochen; Géhin, Martine; Kusic-Pajic, Andjela; Krause, Andreas; Beghetti, Maurice; Dingemanse, Jasper

Published inPaediatric Drugs, vol. 19, no. 2, p. 121-130

Publication date2017

Abstract

Bosentan is approved for use in adult patients with pulmonary arterial hypertension. The primary aim of the pharmacokinetic modeling was the provision of a systematic guidance for study design and enhanced understanding of pharmacokinetics across the entire pediatric age range.

Keywords

Adult
Body Weight
Child
Humans
Hypertension
Pulmonary/drug therapy
Models
Biological
Pediatrics
Sulfonamides/pharmacokinetics

Affiliation entities

Faculté de médecine / Section de médecine clinique / Département de pédiatrie, gynécologie et obstétrique

Research groups

L'hypertension pulmonaire (pédiatrie) (228)

Citation (ISO format)

ZISOWSKY, Jochen et al. Pediatric Development of Bosentan Facilitated by Modeling and Simulation. In: Paediatric Drugs, 2017, vol. 19, n° 2, p. 121–130. doi: 10.1007/s40272-016-0206-0

Article (Published version)

Identifiers

PID : unige:107595
DOI : 10.1007/s40272-016-0206-0
PMID : 28078552

Journal ISSN1174-5878

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Creation05/09/2018 14:26:00

First validation05/09/2018 14:26:00

Update time15/03/2023 09:37:10

Status update15/03/2023 09:37:09

Last indexation31/10/2024 12:01:19

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Pediatric Development of Bosentan Facilitated by Modeling and Simulation

Bosentan is approved for use in adult patients with pulmonary arterial hypertension. The primary aim of the pharmacokinetic modeling was the provision of a systematic guidance for study design and enhanced understanding of pharmacokinetics across the entire pediatric age range.

Technical informations