en
Scientific article
English

Pediatric Development of Bosentan Facilitated by Modeling and Simulation

Published inPaediatric Drugs, vol. 19, no. 2, p. 121-130
Publication date2017
Abstract

Bosentan is approved for use in adult patients with pulmonary arterial hypertension. The primary aim of the pharmacokinetic modeling was the provision of a systematic guidance for study design and enhanced understanding of pharmacokinetics across the entire pediatric age range.

Keywords
  • Adult
  • Body Weight
  • Child
  • Humans
  • Hypertension
  • Pulmonary/drug therapy
  • Models
  • Biological
  • Pediatrics
  • Sulfonamides/pharmacokinetics
Citation (ISO format)
ZISOWSKY, Jochen et al. Pediatric Development of Bosentan Facilitated by Modeling and Simulation. In: Paediatric Drugs, 2017, vol. 19, n° 2, p. 121–130. doi: 10.1007/s40272-016-0206-0
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Article (Published version)
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Identifiers
ISSN of the journal1174-5878
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Technical informations

Creation09/05/2018 12:26:00 PM
First validation09/05/2018 12:26:00 PM
Update time03/15/2023 8:37:10 AM
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