Natural tolerance development in cow's milk allergic children: IgE and IgG4 epitope binding

Caubet, Jean-Christoph Roger J-P; Lin, J; Ahrens, B; Gimenez, G; Bardina, L; Niggemann, B; Sampson, H A; Beyer, K

doi:10.1111/all.13167

Scientific article

English

Natural tolerance development in cow's milk allergic children: IgE and IgG4 epitope binding

ContributorsCaubet, Jean-Christoph Roger J-P; Lin, J; Ahrens, B; Gimenez, G; Bardina, L; Niggemann, B; Sampson, H A; Beyer, K

Published inAllergy, vol. 72, no. 11, p. 1677-1685

Publication date2017

Abstract

Although most of cow's milk (CM) allergic children will outgrow their allergy, the pathomechanism of the natural development of tolerance remains poorly understood. It has been suggested that the balance between milk-specific IgE and IgG4 plays a major role.

Keywords

Animals
Antibody Affinity
Cattle
Epitopes/metabolism
Humans
Immune Tolerance
Immunoglobulin E/immunology/metabolism
Immunoglobulin G/immunology/metabolism
Infant
Milk Hypersensitivity/immunology
Protein Binding

Affiliation

Faculté de médecine / Section de médecine clinique / Département de pédiatrie, gynécologie et obstétrique

Research group

Pathogenèse et traitement des allergies alimentaires (191)

Citation (ISO format)

CAUBET, Jean-Christoph Roger J-P et al. Natural tolerance development in cow’s milk allergic children: IgE and IgG4 epitope binding. In: Allergy, 2017, vol. 72, n° 11, p. 1677–1685. doi: 10.1111/all.13167

Article (Published version)

Identifiers

PID : unige:107583
DOI : 10.1111/all.13167
PMID : 28345783

ISSN of the journal0105-4538

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Natural tolerance development in cow's milk allergic children: IgE and IgG4 epitope binding

Although most of cow's milk (CM) allergic children will outgrow their allergy, the pathomechanism of the natural development of tolerance remains poorly understood. It has been suggested that the balance between milk-specific IgE and IgG4 plays a major role.

Technical informations