Scientific article

Non-IgE-mediated gastrointestinal food allergies in children

Published inPediatric Allergy and Immunology, vol. 28, no. 1, p. 6-17
Publication date2017

Non-IgE-mediated gastrointestinal food allergic disorders (non-IgE-GI-FA) including food protein-induced enterocolitis syndrome (FPIES), food protein-induced enteropathy (FPE), and food protein-induced allergic proctocolitis (FPIAP) are relatively uncommon in infants and young children, but are likely under-diagnosed. Non-IgE-GI-FA have a favorable prognosis, with majority resolving by age 3-5 years. Diagnosis relies on the recognition of symptoms pattern in FPIAP and FPIES and biopsy in FPE. Further studies are needed for a better understanding of the pathomechanism, which will lead eventually to the development of diagnostic tests and treatments. Limited evidence supports the role of food allergens in subsets of constipation, gastroesophageal reflux disease, irritable bowel syndrome, and colic. The immunologic pathomechanism is not fully understood and empiric prolonged avoidance of food allergens should be limited to minimize nutrient deficiency and feeding disorders/food aversions in infants.

  • Allergens/immunology
  • Animals
  • Child
  • Preschool
  • Diet
  • Dietary Proteins/immunology
  • Enterocolitis/diagnosis/diet therapy
  • Food Hypersensitivity/diagnosis/diet therapy
  • Gastrointestinal Diseases/diagnosis/diet therapy
  • Humans
  • Hypersensitivity
  • Delayed/diagnosis/diet therapy
  • Immunoglobulin E/metabolism
  • Infant
  • Infant
  • Newborn
  • Proctocolitis/diagnosis/diet therapy
  • Syndrome
Citation (ISO format)
CAUBET, Jean-Christoph Roger J-P et al. Non-IgE-mediated gastrointestinal food allergies in children. In: Pediatric Allergy and Immunology, 2017, vol. 28, n° 1, p. 6–17. doi: 10.1111/pai.12659
Main files (1)
Article (Published version)
ISSN of the journal0905-6157

Technical informations

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