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Targeted delivery of spironolactone for the treatment of cutaneous and ocular diseases involving mineralocorticoid receptor over-activation

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Defense Thèse de doctorat : Univ. Genève, 2018 - Sc. 5234 - 2018/06/22
Abstract Recently, studies have shown that over activation of the mineralocorticoid receptor is responsible of diseases including delayed wound healing affecting both the cornea and the skin; and central serous chorioretinopathy affecting the posterior segment of the eye. Hence the use of mineralocorticoid receptor antagonists such as spironolactone was suggested as a therapeutic strategy. The aim of this work was to develop novel formulations of spironolactone for the targeted delivery to the eye and to the skin. Spironolactone micelles were successfully developed for topical delivery and showed in vivo tolerability and efficacy for the treatment of corneal delayed wound healing in rabbits and enhanced bioavailability in porcine skin with a preferential transfollicular penetration pathway. A sustained release system was successfully developed and showed release of spironolactone for up to one month after single intravitreal injection in rats. These novel formulations may answer the unmet medical need for the treatment of the above-mentioned diseases.
Keywords Mineralocorticoid receptorSpironolactoneWound healingCentral serous chorioretinopathyMicellesSustained release systemTopical deliveryIntravitreal injection
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URN: urn:nbn:ch:unige-1075283
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DAHMANA, Naoual. Targeted delivery of spironolactone for the treatment of cutaneous and ocular diseases involving mineralocorticoid receptor over-activation. Université de Genève. Thèse, 2018. https://archive-ouverte.unige.ch/unige:107528

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Deposited on : 2018-09-10

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