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Advances in venomics

Oldrati, Vera
Arrell, Miriam
Violette, Aude
Perret, Frédéric
Sprüngli, Xavier
Stöcklin, Reto
Published in Molecular Biosystems. 2016, vol. 12, no. 12, p. 3530-3543
Abstract The term "venomics" was coined to describe the global study of venom and venom glands, targeting comprehensive characterization of the whole toxin profile of a venomous animal by means of proteomics, transcriptomics, genomics and bioinformatics studies. This integrative approach is supported by the rapid evolution of protein, RNA and DNA sequencing techniques, as well as databases, knowledge-bases and biocomputing algorithms. The aim of this review is to illustrate advances in the field of venomics during the last decade, addressing each step of the procedure, from sample collection to data treatment. A special focus is made on new perspectives for a better understanding of the venomous function and for fostering the discovery of new venom-derived drug candidates.
Keywords AnimalsComputational Biology/methodsGenomeGenomics/methodsHigh-Throughput Nucleotide SequencingProteomics/methodsSpecimen HandlingTranscriptomeVenoms/genetics/isolation & purification/metabolism/therapeutic use
PMID: 27787525
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Research group Phytochimie et produits naturels bioactifs
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OLDRATI, Vera et al. Advances in venomics. In: Molecular Biosystems, 2016, vol. 12, n° 12, p. 3530-3543. doi: 10.1039/c6mb00516k https://archive-ouverte.unige.ch/unige:107492

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Deposited on : 2018-09-07

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