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11q deletion in neuroblastoma: a review of biological and clinical implications

Lopez, Gonzalo
Maris, John M
Published in Molecular Cancer. 2017, vol. 16, no. 1, p. 114
Abstract Deletion of the long arm of chromosome 11 (11q deletion) is one of the most frequent events that occur during the development of aggressive neuroblastoma. Clinically, 11q deletion is associated with higher disease stage and decreased survival probability. During the last 25 years, extensive efforts have been invested to identify the precise frequency of 11q aberrations in neuroblastoma, the recurrently involved genes, and to understand the molecular mechanisms of 11q deletion, but definitive answers are still unclear. In this review, it is our intent to compile and review the evidence acquired to date on 11q deletion in neuroblastoma.
Keywords Chromosome DeletionChromosomesHumanPair 11/geneticsDNA Methylation/geneticsGene Regulatory NetworksHaploinsufficiency/geneticsHumansNeuroblastoma/genetics
PMID: 28662712
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Article (Published version) (1.6 MB) - public document Free access
Research group Oncologie et hématologie pédiatrique (907)
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MLAKAR, Vid et al. 11q deletion in neuroblastoma: a review of biological and clinical implications. In: Molecular Cancer, 2017, vol. 16, n° 1, p. 114. doi: 10.1186/s12943-017-0686-8 https://archive-ouverte.unige.ch/unige:107419

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Deposited on : 2018-09-04

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