UNIGE document Scientific Article
previous document  unige:107419  next document
add to browser collection
Title

11q deletion in neuroblastoma: a review of biological and clinical implications

Authors
Lopez, Gonzalo
Maris, John M
Published in Molecular Cancer. 2017, vol. 16, no. 1, p. 114
Abstract Deletion of the long arm of chromosome 11 (11q deletion) is one of the most frequent events that occur during the development of aggressive neuroblastoma. Clinically, 11q deletion is associated with higher disease stage and decreased survival probability. During the last 25 years, extensive efforts have been invested to identify the precise frequency of 11q aberrations in neuroblastoma, the recurrently involved genes, and to understand the molecular mechanisms of 11q deletion, but definitive answers are still unclear. In this review, it is our intent to compile and review the evidence acquired to date on 11q deletion in neuroblastoma.
Keywords Chromosome DeletionChromosomesHumanPair 11/geneticsDNA Methylation/geneticsGene Regulatory NetworksHaploinsufficiency/geneticsHumansNeuroblastoma/genetics
Identifiers
PMID: 28662712
Full text
Article (Published version) (1.6 MB) - public document Free access
Structures
Research group Plateforme d'oncologie et d'hématologie pédiatrique (907)
Citation
(ISO format)
MLAKAR, Vid et al. 11q deletion in neuroblastoma: a review of biological and clinical implications. In: Molecular Cancer, 2017, vol. 16, n° 1, p. 114. https://archive-ouverte.unige.ch/unige:107419

53 hits

7 downloads

Update

Deposited on : 2018-09-04

Export document
Format :
Citation style :