Tropomyosin receptor kinase C (TrkC) expression in medulloblastoma: relation to the molecular subgroups and impact on treatment response

Friedrich, Carsten; Shalaby, Tarek; Oehler, Christoph; Pruschy, Martin; Seifert, Burkhardt; Picard, Daniel; Remke, Marc; Warmuth-Metz, Monika; Kortmann, Rolf-Dieter; Rutkowski, Stefan; Grotzer, Michael A; Von Bueren, André

doi:10.1007/s00381-017-3506-y

Scientific article

English

Tropomyosin receptor kinase C (TrkC) expression in medulloblastoma: relation to the molecular subgroups and impact on treatment response

ContributorsFriedrich, Carsten; Shalaby, Tarek; Oehler, Christoph; Pruschy, Martin; Seifert, Burkhardt; Picard, Daniel; Remke, Marc; Warmuth-Metz, Monika; Kortmann, Rolf-Dieter; Rutkowski, Stefan; Grotzer, Michael A; Von Bueren, André

Published inChild's Nervous System, vol. 33, no. 9, p. 1463-1471

Publication date2017

Abstract

High messenger RNA (mRNA) expression of the tropomyosin receptor kinase C gene (TrkC) has been associated with favorable survival in medulloblastoma patients. Untested is whether it plays a role through modulating the response to therapy or whether it might be a surrogate marker for a favorable molecular subgroup.

Keywords

Adolescent
Biomarkers
Tumor/analysis
Cerebellar Neoplasms/genetics/pathology
Child
Child
Preschool
Female
Humans
Infant
Male
Medulloblastoma/genetics/pathology
Randomized Controlled Trials as Topic
Receptor
TrkC/analysis/biosynthesis
Young Adult

Affiliation entities

Faculté de médecine / Section de médecine clinique / Département de pédiatrie, gynécologie et obstétrique

Research groups

Oncologie et hématologie pédiatrique (907)

Citation (ISO format)

FRIEDRICH, Carsten et al. Tropomyosin receptor kinase C (TrkC) expression in medulloblastoma: relation to the molecular subgroups and impact on treatment response. In: Child’s Nervous System, 2017, vol. 33, n° 9, p. 1463–1471. doi: 10.1007/s00381-017-3506-y

Article (Published version)

Identifiers

PID : unige:107399
DOI : 10.1007/s00381-017-3506-y
PMID : 28695340

Journal ISSN0256-7040

388views

0downloads

Creation04/09/2018 13:48:00

First validation04/09/2018 13:48:00

Update time13/10/2025 19:03:01

Status update15/03/2023 08:34:14

Last indexation09/12/2025 13:27:41

Archive ouverte UNIGE

Tropomyosin receptor kinase C (TrkC) expression in medulloblastoma: relation to the molecular subgroups and impact on treatment response

Technical informations