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Functional atlases for analysis of motor and neuropsychological outcomes after medial globus pallidus and subthalamic stimulation

Publié dansPLOS ONE, vol. 13, no. 7, e0200262
Date de publication2018
Résumé

Anatomical atlases have been developed to improve the targeting of basal ganglia in deep brain stimulation. However, the sole anatomy cannot predict the functional outcome of this surgery. Deep brain stimulation is often a compromise between several functional outcomes: motor, fluency and neuropsychological outcomes in particular. In this study, we have developed anatomo-clinical atlases for the targeting of subthalamic and medial globus pallidus deep brain stimulation. The activated electrode coordinates of 42 patients implanted in the subthalamic nucleus and 29 patients in the medial globus pallidus were studied. The atlas was built using the representation of the volume of tissue theoretically activated by the stimulation. The UPDRS score was used to represent the motor outcome. The Stroop test was represented as well as semantic and phonemic fluencies. For the subthalamic nucleus, best motor outcomes were obtained when the supero-lateral part of the nucleus was stimulated whereas the semantic fluency was impaired in this same region. For the medial globus pallidus, best outcomes were obtained when the postero ventral part of the nucleus was stimulated whereas the phonemic fluency was impaired in this same region. There was no significant neuropsychological impairment. We have proposed new anatomo-clinical atlases to visualize the motor and neuropsychological consequences at 6 months of subthalamic nucleus and pallidal stimulation in patients with Parkinson's disease.

Citation (format ISO)
HAEGELEN, Claire et al. Functional atlases for analysis of motor and neuropsychological outcomes after medial globus pallidus and subthalamic stimulation. In: PLOS ONE, 2018, vol. 13, n° 7, p. e0200262. doi: 10.1371/journal.pone.0200262
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Article (Published version)
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ISSN du journal1932-6203
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Création30.08.2018 13:42:00
Première validation30.08.2018 13:42:00
Heure de mise à jour15.03.2023 08:32:57
Changement de statut15.03.2023 08:32:56
Dernière indexation12.02.2024 11:34:10
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