UNIGE document Doctoral Thesis
previous document  unige:107239  next document
add to browser collection
Title

Natural NF-κB inhibitors for lung cancer chemoprevention

Author
Director
Defense Thèse de doctorat : Univ. Genève, 2018 - Sc. 5228 - 2018/06/08
Abstract Lung cancer is both the most frequent and the most lethal form of cancers worldwide. The vast majority of lung cancers are directly imputable to one risk factor, tobacco smoke, highlighting the preventability of this disease. While tobacco control is the most efficient lung cancer prevention strategy, it seems unrealistic to expect every smoker to quit, owing to the addictiveness of this product and the low success rate of tobacco cessation procedures. Therefore, the development of lung cancer chemoprevention strategies is essential. Among the numerous pathways that can be targeted, NF-κB, a transcription factor that controls inflammation, is particularly interesting. The present work covers various aspects of the preclinical drug discovery process aiming at developing a safe and efficient lung cancer chemopreventive drug from natural sources. It includes the discovery of potent NF-κB inhibitors, the elucidation of their mechanism of action, and the evaluation of their in vivo efficacy.
Keywords Lung cancerChemopreventionNF-κBNatural products
Identifiers
URN: urn:nbn:ch:unige-1072397
Full text
Thesis (5 MB) - private document Private access (until 2020-08-21)
Structures
Research group Pharmacognosie
Citation
(ISO format)
MONTEILLIER, Aymeric. Natural NF-κB inhibitors for lung cancer chemoprevention. Université de Genève. Thèse, 2018. https://archive-ouverte.unige.ch/unige:107239

75 hits

0 download

Update

Deposited on : 2018-08-27

Export document
Format :
Citation style :