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Doctoral thesis
English

Natural NF-κB inhibitors for lung cancer chemoprevention

Defense date2018-06-08
Abstract

Lung cancer is both the most frequent and the most lethal form of cancers worldwide. The vast majority of lung cancers are directly imputable to one risk factor, tobacco smoke, highlighting the preventability of this disease. While tobacco control is the most efficient lung cancer prevention strategy, it seems unrealistic to expect every smoker to quit, owing to the addictiveness of this product and the low success rate of tobacco cessation procedures. Therefore, the development of lung cancer chemoprevention strategies is essential. Among the numerous pathways that can be targeted, NF-κB, a transcription factor that controls inflammation, is particularly interesting. The present work covers various aspects of the preclinical drug discovery process aiming at developing a safe and efficient lung cancer chemopreventive drug from natural sources. It includes the discovery of potent NF-κB inhibitors, the elucidation of their mechanism of action, and the evaluation of their in vivo efficacy.

eng
Keywords
  • Lung cancer
  • Chemoprevention
  • NF-κB
  • Natural products
Research group
Citation (ISO format)
MONTEILLIER, Aymeric. Natural NF-κB inhibitors for lung cancer chemoprevention. 2018. doi: 10.13097/archive-ouverte/unige:107239
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Creation08/21/2018 5:12:00 PM
First validation08/21/2018 5:12:00 PM
Update time03/15/2023 8:32:26 AM
Status update03/15/2023 8:32:26 AM
Last indexation01/29/2024 9:34:30 PM
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