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Limbic encephalitis associated with systemic sclerosis

De Stefano, Pia
Lalive, Patrice H
Lascano, Agustina M
Published in Multiple Sclerosis and Related Disorders. 2018, vol. 24, p. 142-144
Abstract We report the case of a patient affected by systemic sclerosis (SSc) who developed autoimmune limbic encephalitis, which improved under immunosuppressant agents and high-dose intravenous immunoglobulins. In our patient the autoimmune encephalitis occurred during apparently quiescent SSc, though concomitantly with novel arthritis. Moreover, our patient showed auto-antibodies directed against SSA antigen but the panel of auto-antibodies associated with autoimmune encephalitis was negative. We discuss the potential for immunopathogenic inflammatory events affecting the central nervous system in SSc then favoring the occurrence of autoimmune encephalitic disorders. The possibility of a "neuro-scleroderma" may have important consequences in terms of therapeutic approaches.
PMID: 30005357
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DE STEFANO, Pia et al. Limbic encephalitis associated with systemic sclerosis. In: Multiple Sclerosis and Related Disorders, 2018, vol. 24, p. 142-144. https://archive-ouverte.unige.ch/unige:107109

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Deposited on : 2018-08-16

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