UNIGE document Scientific Article
previous document  unige:106681  next document
add to browser collection
Title

Pupil Size Coupling to Cortical States Protects the Stability of Deep Sleep via Parasympathetic Modulation

Authors
Published in Current Biology. 2018, vol. 28, no. 3, p. 392-400.e3
Abstract During wakefulness, pupil diameter can reflect changes in attention, vigilance, and cortical states. How pupil size relates to cortical activity during sleep, however, remains unknown. Pupillometry during natural sleep is inherently challenging since the eyelids are usually closed. Here, we present a novel head-fixed sleep paradigm in combination with infrared back-illumination pupillometry (iBip) allowing robust tracking of pupil diameter in sleeping mice. We found that pupil size can be used as a reliable indicator of sleep states and that cortical activity becomes tightly coupled to pupil size fluctuations during non-rapid eye movement (NREM) sleep. Pharmacological blocking experiments indicate that the observed pupil size changes during sleep are mediated via the parasympathetic system. We furthermore found that constrictions of the pupil during NREM episodes might play a protective role for stability of sleep depth. These findings reveal a fundamental relationship between cortical activity and pupil size, which has so far been hidden behind closed eyelids.
Keywords Pupil trackingSleepParasympatheticSleep spindlesMouseHead fixedInfrared back-illumination pupillometryEEGUltra-slow oscillations
Identifiers
PMID: 29358069
Full text
Structures
Research group Groupe Huber Daniel (neurosciences fondamentales) (914)
Citation
(ISO format)
YUZGEC, Ozge et al. Pupil Size Coupling to Cortical States Protects the Stability of Deep Sleep via Parasympathetic Modulation. In: Current Biology, 2018, vol. 28, n° 3, p. 392-400.e3. doi: 10.1016/j.cub.2017.12.049 https://archive-ouverte.unige.ch/unige:106681

316 hits

139 downloads

Update

Deposited on : 2018-07-25

Export document
Format :
Citation style :