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Title

Implication of sperm RNAs in transgenerational inheritance of the effects of early trauma in mice

Authors
Gapp, Katharina
Jawaid, Ali
Sarkies, Peter
Bohacek, Johannes
Pelczar, Pawel
Farinelli, Laurent
Miska, Eric
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Published in Nature Neuroscience. 2014, vol. 17, no. 5, p. 667-669
Abstract Small non-coding RNAs (sncRNAs) are potential vectors at the interface between genes and environment. We found that traumatic stress in early life altered mouse microRNA (miRNA) expression, and behavioral and metabolic responses in the progeny. Injection of sperm RNAs from traumatized males into fertilized wild-type oocytes reproduced the behavioral and metabolic alterations in the resulting offspring.
Keywords MiRANSncRNATransgenerationalSperm
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PMID: 24728267
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Article (Published version) (331 Kb) - document accessible for UNIGE members only Limited access to UNIGE
Other version: http://www.nature.com/articles/nn.3695
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Research group Brain Research Institute, Neuroscience Center Zürich, University of Zürich and Swiss Federal Institute of Technology, Zürich, Switzerland.
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GAPP, Katharina et al. Implication of sperm RNAs in transgenerational inheritance of the effects of early trauma in mice. In: Nature Neuroscience, 2014, vol. 17, n° 5, p. 667-669. https://archive-ouverte.unige.ch/unige:106627

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Deposited on : 2018-07-24

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