Implication of sperm RNAs in transgenerational inheritance of the effects of early trauma in mice

Gapp, Katharina; Jawaid, Ali; Sarkies, Peter; Bohacek, Johannes; Pelczar, Pawel; Prados, Julien; Farinelli, Laurent; Miska, Eric; Mansuy, Isabelle M

doi:10.1038/nn.3695

Scientific article

English

Implication of sperm RNAs in transgenerational inheritance of the effects of early trauma in mice

ContributorsGapp, Katharina; Jawaid, Ali; Sarkies, Peter; Bohacek, Johannes; Pelczar, Pawel; Prados, Julien

; Farinelli, Laurent; Miska, Eric; Mansuy, Isabelle M

Published inNature Neuroscience, vol. 17, no. 5, p. 667-669

Publication date2014

Abstract

Small non-coding RNAs (sncRNAs) are potential vectors at the interface between genes and environment. We found that traumatic stress in early life altered mouse microRNA (miRNA) expression, and behavioral and metabolic responses in the progeny. Injection of sperm RNAs from traumatized males into fertilized wild-type oocytes reproduced the behavioral and metabolic alterations in the resulting offspring.

Keywords

MiRAN
SncRNA
Transgenerational
Sperm

Affiliation entities

Faculté de médecine / Section de médecine clinique / Département de psychiatrie

Citation (ISO format)

GAPP, Katharina et al. Implication of sperm RNAs in transgenerational inheritance of the effects of early trauma in mice. In: Nature Neuroscience, 2014, vol. 17, n° 5, p. 667–669. doi: 10.1038/nn.3695

Article (Published version)

Identifiers

PID : unige:106627
DOI : 10.1038/nn.3695
PMID : 24728267

Additional URL for this publicationhttp://www.nature.com/articles/nn.3695

Journal ISSN1097-6256

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Implication of sperm RNAs in transgenerational inheritance of the effects of early trauma in mice

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