Scientific article
OA Policy
English

Influence of cell mechanics and proliferation on the buckling of simulated tissues using a vertex model

Published inNatural Computing, p. 1-9
Publication date2017
Abstract

Tissue folding is a frequently observed phenomenon, from the cerebral cortex gyrification, to the gut villi formation and even the crocodile head scales development. Although its causes are not yet well understood, some hypotheses suggest that it is related to the physical properties of the tissue and its growth under mechanical constraints. In order to study the underlying mechanisms affecting tissue folding, experimental models are developed where epithelium monolayers are cultured inside hydrogel microcapsules. In this work, we use a 2D vertex model of circular cross-sections of cell monolayers to investigate how cell mechanical properties and proliferation affect the shape of in-silico growing tissues. We observe that increasing the cells' contractility and the intercellular adhesion reduces tissue buckling. This is found to coincide with smaller and thicker cross-sections that are characterized by shorter relaxation times following cell division. Finally, we show that the smooth or folded morphology of the simulated monolayers also depends on the combination of the cell proliferation rate and the tissue size.

Keywords
  • Vertex model
  • Cell monolayer
  • Numerical simulations
  • Buckling
  • Cell mechanics
  • Proliferation
  • Growth
Citation (ISO format)
MERZOUKI, Fatma Aziza et al. Influence of cell mechanics and proliferation on the buckling of simulated tissues using a vertex model. In: Natural Computing, 2017, p. 1–9. doi: 10.1007/s11047-017-9629-y
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Article (Published version)
accessLevelPublic
Identifiers
Additional URL for this publicationhttp://link.springer.com/10.1007/s11047-017-9629-y
Journal ISSN1567-7818
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566downloads

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