Magnesium homeostasis in Staphylococcus aureus

ContributorsTrachsel, Emilie
Master program titleMaîtrise universitaire (Master) en Biologie, orientation libre
Defense date2018

Staphylococcus aureus, an opportunistic pathogen present in the nasal cavities of approximatively 25% of the healthy population, causes thousands of deaths per year in the United States alone. This bacterium supports hundreds of millimolar of magnesium (up to 770mM), a concentration much higher than many other bacteria. To maintain intracellular magnesium concentrations within a physiological range bacteria make use of active importers and probably exporters. Here, we study the magnesium homeostasis in Staphylococcus aureus and more precisely the roles of the putative magnesium transporters: mpfA, mpfB, corA1, corA2 and mgtE. We focus mainly on the mutations that appeared to compensate the magnesium sensitivity due to the loss of MpfA, a putative magnesium exporter. We also investigate the question of which importer(s) is/are fundamental for the growth and show that magnesium import in S. aureus relies on the dual activity of both CorA2 and MgtE.

Citation (ISO format)
TRACHSEL, Emilie. Magnesium homeostasis in Staphylococcus aureus. 2018.
Main files (1)
Master thesis
  • PID : unige:106044

Technical informations

Creation07/03/2018 9:07:00 AM
First validation07/03/2018 9:07:00 AM
Update time03/15/2023 8:22:59 AM
Status update03/15/2023 8:22:58 AM
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