Scientific article
Open access

Interaction between personality traits and cerebrospinal fluid biomarkers of Alzheimer's disease pathology modulates cognitive performance

Published inAlzheimer's Research and Therapy, vol. 9, no. 1, 6
Publication date2017

During adulthood, personality characteristics may contribute to the individual capacity to compensate the impact of developing cerebral Alzheimer's disease (AD) pathology on cognitive impairment in later life. In this study we aimed to investigate whether and how premorbid personality traits interact with cerebrospinal fluid (CSF) markers of AD pathology to predict cognitive performance in subjects with mild cognitive impairment or mild AD dementia and in participants with normal cognition.

  • Aged
  • Alzheimer Disease/cerebrospinal fluid/genetics/psychology
  • Apolipoprotein E4/genetics
  • Biomarkers/cerebrospinal fluid
  • Cognition/physiology
  • Cognitive Dysfunction/cerebrospinal fluid/genetics/psychology
  • Female
  • Humans
  • Male
  • Multivariate Analysis
  • Neuropsychological Tests
  • Personality/genetics/physiology
  • Regression Analysis
  • Retrospective Studies
  • Spinal Puncture
Affiliation Not a UNIGE publication
Citation (ISO format)
TAUTVYDAITE, Domile et al. Interaction between personality traits and cerebrospinal fluid biomarkers of Alzheimer’s disease pathology modulates cognitive performance. In: Alzheimer’s Research and Therapy, 2017, vol. 9, n° 1, p. 6. doi: 10.1186/s13195-017-0235-0
Main files (1)
Article (Published version)
ISSN of the journal1758-9193

Technical informations

Creation06/08/2018 9:35:00 AM
First validation06/08/2018 9:35:00 AM
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