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Title

One-carbon metabolism, cognitive impairment and CSF measures of Alzheimer pathology: homocysteine and beyond

Authors
Guiraud, Seu Ping
Corthésy, John
Da Silva, Laeticia
Migliavacca, Eugenia
Tautvydaitė, Domilė
Oikonomidi, Aikaterini
Moullet, Barbara
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Published in Alzheimer's Research and Therapy. 2017, vol. 9, no. 1, p. 43
Abstract Hyperhomocysteinemia is a risk factor for cognitive decline and dementia, including Alzheimer disease (AD). Homocysteine (Hcy) is a sulfur-containing amino acid and metabolite of the methionine pathway. The interrelated methionine, purine, and thymidylate cycles constitute the one-carbon metabolism that plays a critical role in the synthesis of DNA, neurotransmitters, phospholipids, and myelin. In this study, we tested the hypothesis that one-carbon metabolites beyond Hcy are relevant to cognitive function and cerebrospinal fluid (CSF) measures of AD pathology in older adults.
Keywords AgedAlzheimer Disease/cerebrospinal fluid/diagnosis/epidemiologyBiomarkers/blood/cerebrospinal fluidCarbon/bloodCarbon Compounds, Inorganic/cerebrospinal fluidCognition Disorders/cerebrospinal fluid/diagnosis/epidemiologyComorbidityFemaleHomocysteine/cerebrospinal fluidHumansMalePrevalenceRisk FactorsSwitzerland/epidemiology
Identifiers
PMID: 28623948
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Article (Published version) (1 MB) - public document Free access
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Research group Neuropsychiatrie et Biomarqueurs de la maladie d'Alzheimer (991)
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DAYON, Loic et al. One-carbon metabolism, cognitive impairment and CSF measures of Alzheimer pathology: homocysteine and beyond. In: Alzheimer's Research and Therapy, 2017, vol. 9, n° 1, p. 43. https://archive-ouverte.unige.ch/unige:105775

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Deposited on : 2018-06-20

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