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One-carbon metabolism, cognitive impairment and CSF measures of Alzheimer pathology: homocysteine and beyond |
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Published in | Alzheimer's research & therapy. 2017, vol. 9, no. 1, 43 | |
Abstract | Hyperhomocysteinemia is a risk factor for cognitive decline and dementia, including Alzheimer disease (AD). Homocysteine (Hcy) is a sulfur-containing amino acid and metabolite of the methionine pathway. The interrelated methionine, purine, and thymidylate cycles constitute the one-carbon metabolism that plays a critical role in the synthesis of DNA, neurotransmitters, phospholipids, and myelin. In this study, we tested the hypothesis that one-carbon metabolites beyond Hcy are relevant to cognitive function and cerebrospinal fluid (CSF) measures of AD pathology in older adults. | |
Keywords | Aged — Alzheimer Disease/cerebrospinal fluid/diagnosis/epidemiology — Biomarkers/blood/cerebrospinal fluid — Carbon/blood — Carbon Compounds, Inorganic/cerebrospinal fluid — Cognition Disorders/cerebrospinal fluid/diagnosis/epidemiology — Comorbidity — Female — Homocysteine/cerebrospinal fluid — Humans — Male — Prevalence — Risk Factors — Switzerland/epidemiology | |
Identifiers | PMID: 28623948 | |
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Research group | Neuropsychiatrie et Biomarqueurs de la maladie d'Alzheimer (991) | |
Citation (ISO format) | DAYON, Loic et al. One-carbon metabolism, cognitive impairment and CSF measures of Alzheimer pathology: homocysteine and beyond. In: Alzheimer's Research and Therapy, 2017, vol. 9, n° 1, p. 43. doi: 10.1186/s13195-017-0270-x https://archive-ouverte.unige.ch/unige:105775 |