One-carbon metabolism, cognitive impairment and CSF measures of Alzheimer pathology: homocysteine and beyond

Dayon, Loic; Guiraud, Seu Ping; Corthésy, John; Da Silva, Laeticia; Migliavacca, Eugenia; Tautvydaitė, Domilė; Oikonomidi, Aikaterini; Moullet, Barbara; Henry, Hugues; Métairon, Sylviane; Marquis, Julien; Descombes, Patrick; Collino, Sebastiano; Martin, François-Pierre J; Montoliu, Ivan; Kussmann, Martin; Wojcik, Jérôme; Bowman, Gene L; Popp, Julius

doi:10.1186/s13195-017-0270-x

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Title		One-carbon metabolism, cognitive impairment and CSF measures of Alzheimer pathology: homocysteine and beyond
Authors		Dayon, Loic Guiraud, Seu Ping Corthésy, John Da Silva, Laeticia Migliavacca, Eugenia Tautvydaitė, Domilė Oikonomidi, Aikaterini Moullet, Barbara Henry, Hugues Métairon, Sylviane Marquis, Julien Descombes, Patrick Collino, Sebastiano Martin, François-Pierre J Montoliu, Ivan Kussmann, Martin Wojcik, Jérôme Bowman, Gene L Popp, Julius show all authors [1 - 19]
Published in		Alzheimer's Research and Therapy. 2017, vol. 9, no. 1, p. 43
Abstract		Hyperhomocysteinemia is a risk factor for cognitive decline and dementia, including Alzheimer disease (AD). Homocysteine (Hcy) is a sulfur-containing amino acid and metabolite of the methionine pathway. The interrelated methionine, purine, and thymidylate cycles constitute the one-carbon metabolism that plays a critical role in the synthesis of DNA, neurotransmitters, phospholipids, and myelin. In this study, we tested the hypothesis that one-carbon metabolites beyond Hcy are relevant to cognitive function and cerebrospinal fluid (CSF) measures of AD pathology in older adults.
Keywords		Aged — Alzheimer Disease/cerebrospinal fluid/diagnosis/epidemiology — Biomarkers/blood/cerebrospinal fluid — Carbon/blood — Carbon Compounds, Inorganic/cerebrospinal fluid — Cognition Disorders/cerebrospinal fluid/diagnosis/epidemiology — Comorbidity — Female — Homocysteine/cerebrospinal fluid — Humans — Male — Prevalence — Risk Factors — Switzerland/epidemiology
Identifiers		DOI: 10.1186/s13195-017-0270-x PMID: 28623948
Full text		Article (Published version) (1 MB) - Free access
Structures		Faculté de médecine / Section de médecine clinique / Département de psychiatrie
Research group		Neuropsychiatrie et Biomarqueurs de la maladie d'Alzheimer (991)
Citation (ISO format)		DAYON, Loic et al. One-carbon metabolism, cognitive impairment and CSF measures of Alzheimer pathology: homocysteine and beyond. In: Alzheimer's Research and Therapy, 2017, vol. 9, n° 1, p. 43. doi: 10.1186/s13195-017-0270-x https://archive-ouverte.unige.ch/unige:105775