Macrophage Migration Inhibitory Factor is Associated with Biomarkers of Alzheimer's Disease Pathology and Predicts Cognitive Decline in Mild Cognitive Impairment and Mild Dementia

Oikonomidi, Aikaterini; Tautvydaite, Domile; Gholamrezaee, Mehdi M; Henry, Hugues; Bacher, Michael; Popp, Julius

doi:10.3233/JAD-170335

Scientific article

English

Macrophage Migration Inhibitory Factor is Associated with Biomarkers of Alzheimer's Disease Pathology and Predicts Cognitive Decline in Mild Cognitive Impairment and Mild Dementia

ContributorsOikonomidi, Aikaterini; Tautvydaite, Domile; Gholamrezaee, Mehdi M; Henry, Hugues; Bacher, Michael; Popp, Julius

Published inJournal of Alzheimer's Disease, vol. 60, no. 1, p. 273-281

Publication date2017

Abstract

Macrophage migration inhibitory factor (MIF) is a pro-inflammatory protein playing a regulatory role in the immune response. First evidence from in vitro and animal studies suggests that MIF may be involved in the development of Alzheimer's disease (AD) pathology.

Keywords

Aged
Aged, 80 and over
Amyloid beta-Peptides/blood/cerebrospinal fluid
Apolipoproteins E/genetics
Cognitive Dysfunction/blood/cerebrospinal fluid/genetics/physiopathology
Dementia/blood/cerebrospinal fluid/genetics/physiopathology
Female
Humans
Intramolecular Oxidoreductases/blood/cerebrospinal fluid
Macrophage Migration-Inhibitory Factors/blood/cerebrospinal fluid
Male
Middle Aged
Neuropsychological Tests
Peptide Fragments/blood/cerebrospinal fluid
Psychiatric Status Rating Scales
tau Proteins/blood/cerebrospinal fluid

Affiliation entities

Not a UNIGE publication

Citation (ISO format)

OIKONOMIDI, Aikaterini et al. Macrophage Migration Inhibitory Factor is Associated with Biomarkers of Alzheimer’s Disease Pathology and Predicts Cognitive Decline in Mild Cognitive Impairment and Mild Dementia. In: Journal of Alzheimer’s Disease, 2017, vol. 60, n° 1, p. 273–281. doi: 10.3233/JAD-170335

Article (Published version)

Identifiers

PID : unige:105773
DOI : 10.3233/JAD-170335
PMID : 28826184

Journal ISSN1387-2877

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Macrophage Migration Inhibitory Factor is Associated with Biomarkers of Alzheimer's Disease Pathology and Predicts Cognitive Decline in Mild Cognitive Impairment and Mild Dementia

Macrophage migration inhibitory factor (MIF) is a pro-inflammatory protein playing a regulatory role in the immune response. First evidence from in vitro and animal studies suggests that MIF may be involved in the development of Alzheimer's disease (AD) pathology.

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