Selective pharmacological inhibition of DDR1 prevents experimentally-induced glomerulonephritis in prevention and therapeutic regime

Moll, Solange; Yasui, Yukari; Abed, Ahmed; Murata, Takeshi; Shimada, Hideaki; Maeda, Akira; Fukushima, Naoshi; Kanamori, Masakazu; Uhles, Sabine; Badi, Laura; Cagarelli, Thomas; Formentini, Ivan; Drawnel, Faye; Georges, Guy; Bergauer, Tobias; Gasser, Rodolfo; Bonfil, R Daniel; Fridman, Rafael; Richter, Hans; Funk, Juergen; Moeller, Marcus J; Chatziantoniou, Christos; Prunotto, Marco

doi:10.1186/s12967-018-1524-5

Scientific article

English

Selective pharmacological inhibition of DDR1 prevents experimentally-induced glomerulonephritis in prevention and therapeutic regime

Published inJournal of Translational Medicine, vol. 16, no. 1, 148

Publication date2018

Abstract

Discoidin domain receptor 1 (DDR1) is a collagen-activated receptor tyrosine kinase extensively implicated in diseases such as cancer, atherosclerosis and fibrosis. Multiple preclinical studies, performed using either a gene deletion or a gene silencing approaches, have shown this receptor being a major driver target of fibrosis and glomerulosclerosis.

Affiliation entities

Faculté de médecine / Section de médecine fondamentale / Département de pathologie et immunologie

Research groups

Analyse protéomique et Analyse génomique des maladies rénales (659)

Citation (ISO format)

MOLL, Solange et al. Selective pharmacological inhibition of DDR1 prevents experimentally-induced glomerulonephritis in prevention and therapeutic regime. In: Journal of Translational Medicine, 2018, vol. 16, n° 1, p. 148. doi: 10.1186/s12967-018-1524-5