Scientific article
Open access

Copper-catalyzed enantioselective 1,2-borylation of 1,3-dienes

Published inChemical Science, vol. 9, no. 23, p. 5284-5288
Publication date2018

A highly enantioselective Cu-catalyzed borylation of 2-substituted 1,3-dienes is reported. The use of a chiral phosphanamine ligand is essential in achieving high chemo-, regio-, diastereo- and enantioselectivity. It provides access to a variety of homoallylic boronates in consistently high yield and enantiomeric excess with 2-aryl and 2-heteroaryl 1,3-dienes as well as sterically demanding 2-alkyl 1,3-dienes. Preliminary investigations based on a non-linear effect study point to a mechanism involving more than one metal center.

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Citation (ISO format)
LIU, Yangbin, FIORITO, Daniele, MAZET, Clement. Copper-catalyzed enantioselective 1,2-borylation of 1,3-dienes. In: Chemical Science, 2018, vol. 9, n° 23, p. 5284–5288. doi: 10.1039/C8SC01538D
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Article (Published version)
ISSN of the journal2041-6520

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Creation06/18/2018 12:08:00 PM
First validation06/18/2018 12:08:00 PM
Update time03/15/2023 8:20:50 AM
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