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Neural dynamics of social threat processing through intracranial recordings of the human amygdala and orbitofrontal cortex

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Defense Thèse de doctorat : Univ. Genève, 2016 - FPSE 636 - 2016/11/04
Abstract Social threat processing and flexible behavioral adjustments rely on widespread and complex neural network activity, anchored by the amygdala and the orbitofrontal cortex. Although anatomical and imaging studies suggest a potential interplay between these areas, the mechanisms and nature of this interaction remain unknown. By analyzing intracranial recordings in humans, we show selective enhancement in low-frequency phase-locking synchronization and long-range phase-amplitude coupling between low-frequency signals in the amygdala and gamma signals in the orbitofrontal cortex during processing of angry relative to neutral facial or vocal expressions. Behaviorally, enhanced amygdalo-orbitofrontal cortex coupling was linked to faster reaction times for angry relative to neutral stimuli. These results provide unique evidence of a direct functional communication within the amygdalo-orbitofrontal network, supporting rapid social threat processing and behavioral adjustment.
Keywords AmygdalaOrbitofrontal cortex (OFC)Neural dynamicsNeural synchronizationEmotional prosodyEmotional facesSpatial attention
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URN: urn:nbn:ch:unige-1053003
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Other version: https://nbn-resolving.org/urn:nbn:ch:unige-1053003
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Research groups Neuroscience de l'émotion et dynamiques affectives (NEAD)
Groupe Anne-Lise Giraud (939)
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CHRISTEN, Andy. Neural dynamics of social threat processing through intracranial recordings of the human amygdala and orbitofrontal cortex. Université de Genève. Thèse, 2016. https://archive-ouverte.unige.ch/unige:105300

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Deposited on : 2018-06-11

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