Social threat processing and flexible behavioral adjustments rely on widespread and complex neural network activity, anchored by the amygdala and the orbitofrontal cortex. Although anatomical and imaging studies suggest a potential interplay between these areas, the mechanisms and nature of this interaction remain unknown. By analyzing intracranial recordings in humans, we show selective enhancement in low-frequency phase-locking synchronization and long-range phase-amplitude coupling between low-frequency signals in the amygdala and gamma signals in the orbitofrontal cortex during processing of angry relative to neutral facial or vocal expressions. Behaviorally, enhanced amygdalo-orbitofrontal cortex coupling was linked to faster reaction times for angry relative to neutral stimuli. These results provide unique evidence of a direct functional communication within the amygdalo-orbitofrontal network, supporting rapid social threat processing and behavioral adjustment.