Hybrid PET-MRI in Alzheimer&#039;s Disease Research

Mainta, Ismini Charis; Vargas Gomez, Maria Isabel; Trombella, Sara; Frisoni, Giovanni; Unschuld, Paul; Garibotto, Valentina

doi:10.1007/978-1-4939-7704-8_12

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Title		Hybrid PET-MRI in Alzheimer's Disease Research
Authors		Mainta, Ismini Charis Vargas Gomez, Maria Isabel Trombella, Sara Frisoni, Giovanni Unschuld, Paul Garibotto, Valentina
Published in		Methods in molecular biology. 2018, vol. 1750, p. 185-200
Abstract		Multiple factors, namely amyloid, tau, inflammation, metabolic, and perfusion changes, contribute to the cascade of neurodegeneration and functional decline occurring in Alzheimer's disease (AD). These molecular and cellular processes and related functional and morphological changes can be visualized in vivo by two imaging modalities, namely positron emission tomography (PET) and magnetic resonance imaging (MRI). These imaging biomarkers are now part of the diagnostic algorithm and of particular interest for patient stratification and targeted drug development.In this field the availability of hybrid PET/MR systems not only offers a comprehensive evaluation in a single imaging session, but also opens new possibilities for the integration of the two imaging information. Here, we cover the clinical protocols and practical details of FDG, amyloid, and tau PET/MR imaging as applied in our institutions.
Identifiers		DOI: 10.1007/978-1-4939-7704-8_12 PMID: 29512073
Full text		Article (Published version) (821 Kb) - Limited access to UNIGE
Structures		Faculté de médecine / Section de médecine clinique / Département de radiologie et informatique médicale
Research groups		Laboratoire de neuroimagerie et de traceurs moléculaires innovants (984) Optimisations des techniques avancés en neuroimagerie (985) Troubles de mémoire et maladie d'Alzeimer (935)
Citation (ISO format)		MAINTA, Ismini Charis et al. Hybrid PET-MRI in Alzheimer's Disease Research. In: Methods in Molecular Biology, 2018, vol. 1750, p. 185-200. doi: 10.1007/978-1-4939-7704-8_12 https://archive-ouverte.unige.ch/unige:104802