Cell-specific resetting of mouse islet cellular clocks by glucagon, glucagon-like peptide 1 and somatostatin

Petrenko, Volodymyr; Dibner, Charna

doi:10.1111/apha.13021

Scientific article

English

Cell-specific resetting of mouse islet cellular clocks by glucagon, glucagon-like peptide 1 and somatostatin

ContributorsPetrenko, Volodymyr; Dibner, Charna

Published inActa Physiologica, vol. 222, no. 4, e13021

Publication date2018

Abstract

Molecular clocks, operative in pancreatic islet cells, represent an intrinsic mechanism regulating intracellular metabolism and hormone secretion. Glucagon, somatostatin and glucagon-like peptide 1 (GLP-1) are essential coordinators of islet physiology. Here, we assess the synchronizing capacity of glucagon, somatostatin and GLP-1 on pancreatic α- and β-cell circadian clocks.

Keywords

Circadian bioluminescence
Circadian oscillator
Glucagon
Glucagon-like peptide 1
Somatostatin
α- and β-islet cells

Affiliation entities

Faculté de médecine / Section de médecine clinique / Département de médecine

Research groups

Endocrinologie et horloge circadienne (948)

Funding

Swiss National Science Foundation - Roles of the circadian oscillator in pancreatic islet function, failure and regeneration [166700]

Citation (ISO format)

PETRENKO, Volodymyr, DIBNER, Charna. Cell-specific resetting of mouse islet cellular clocks by glucagon, glucagon-like peptide 1 and somatostatin. In: Acta Physiologica, 2018, vol. 222, n° 4, p. e13021. doi: 10.1111/apha.13021

Article (Published version)

Identifiers

PID : unige:104597
DOI : 10.1111/apha.13021
PMID : 29271578

Journal ISSN1748-1708

519views

9downloads

Creation10/04/2018 14:39:00

First validation10/04/2018 14:39:00

Update time20/01/2025 09:24:55

Status update20/01/2025 09:24:55

Last indexation20/01/2025 09:40:26

Archive ouverte UNIGE

Cell-specific resetting of mouse islet cellular clocks by glucagon, glucagon-like peptide 1 and somatostatin

Technical informations