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Title

Cerebrospinal fluid concentrations of atracurium, laudanosine and vecuronium following clinical subarachnoid hemorrhage
Authors
Tassonyi, Edomer
Fathi, Marc
Hughes, G. J.
Chiodini, F.
Bertrand, Daniel
Muller, Dominique
Fuchs-Buder, T.
Published in Acta anaesthesiologica Scandinavica. 2002, vol. 46, no. 10, p. 1236-1241
Abstract BACKGROUND: Neuromuscular blocking agents may exert central nervous system effects when they reach the brain. This study assessed the concentrations and the time course of passage of vecuronium, atracurium, and its metabolite laudanosine in the cerebrospinal fluid (CSF) of patients undergoing intracranial aneurysm clipping. METHODS: Twenty-five patients with subarachnoid hemorrhage were randomly allocated to receive an intravenous infusion of vecuronium (n=13) or atracurium (n=12). Arterial blood and lumbar CSF were sampled before and 1, 2, 3, 4 and 8 h after the start of the relaxant infusion. The samples were analyzed by liquid chromatography-electrospray ionization mass spectrometry (vecuronium) and high-pressure liquid chromatography (atracurium and laudanosine). RESULTS: The data of 20 patients (10 in both groups) were analyzed. In 11 CSF samples from five patients atracurium was detected in concentrations from 10 to 50 ng/ml. Laudanosine was retrieved in all CSF samples at 1, 2, 3, 4 and 8 h; the highest CSF concentration of laudanosine occurred at 3 h [38 (18-63) ng/ml: median (range)]. Vecuronium was not found in any CSF sample. CONCLUSION: Significant concentrations of atracurium and laudanosine but not of vecuronium were detected in the CSF of patients during and immediately after intracranial aneurysm surgery.
Keywords Adolescent — Adult — Aged — Analysis of Variance — Atracurium/blood/ cerebrospinal fluid/ pharmacokinetics — Central Nervous System Agents/blood/ cerebrospinal fluid/ pharmacokinetics — Female — Humans — Intracranial Aneurysm/ surgery — Isoquinolines/blood/ cerebrospinal fluid/ pharmacokinetics — Male — Middle Aged — Neuromuscular Nondepolarizing Agents/blood/ cerebrospinal fluid/ pharmacokinetics — Subarachnoid Hemorrhage/ physiopathology — Time Factors — Vecuronium Bromide/blood/ cerebrospinal fluid/ pharmacokinetics
Identifiers
PMID: 12421196
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Structures
Faculté de médecine / Section de médecine fondamentale / Département de neurosciences fondamentales
Citation
(ISO format) 		TASSONYI, Edomer et al. Cerebrospinal fluid concentrations of atracurium, laudanosine and vecuronium following clinical subarachnoid hemorrhage. In: Acta anaesthesiologica Scandinavica, 2002, vol. 46, n° 10, p. 1236-1241. doi: 10.1034/j.1399-6576.2002.461011.x https://archive-ouverte.unige.ch/unige:10459

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Deposited on : 2010-08-06

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