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Title

Glial response to 17β-estradiol in neonatal rats with excitotoxic brain injury

Authors
Pansiot, Julien
Pham, Hoa
Dalous, Jeremie
Chevenne, Didier
Colella, Marina
Schwendimann, Leslie
Fafouri, Assia
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Published in Experimental Neurology. 2016, vol. 282, p. 56-65
Abstract White-matter injury is the most common cause of the adverse neurodevelopmental outcomes observed in preterm infants. Only few options exist to prevent perinatal brain injury associated to preterm delivery. 17β-estradiol (E2) is the predominant estrogen in circulation and has been shown to be neuroprotective in vitro and in vivo. However, while E2 has been found to modulate inflammation in adult models of brain damage, how estrogens influence glial cells response in the developing brain needs further investigations. Using a model of ibotenate-induced brain injury, we have refined the effects of E2 in the developing brain. E2 provides significant neuroprotection both in the cortical plate and the white matter in neonatal rats subjected to excitotoxic insult mimicking white matter and cortical damages frequently observed in very preterm infants. E2 promotes significant changes in microglial phenotypes balance in response to brain injury and the acceleration of oligodendrocyte maturation. Maturational effects of E2 on myelination process were observed both in vivo and in vitro. Altogether, these data demonstrate that response of glial cells to E2 could be responsible for its neuroprotective properties in neonatal excitotoxic brain injury.
Keywords Adenomatous Polyposis Coli Protein/metabolismAnimalsAnimals, NewbornBasic Helix-Loop-Helix Transcription Factors/metabolismCells, CulturedCerebral Cortex/cytologyCytokines/genetics/metabolismDisease Models, AnimalDose-Response Relationship, DrugEmbryo, MammalianEstradiol/pharmacology/therapeutic useExcitatory Amino Acid Agonists/toxicityIbotenic Acid/toxicityLeukoencephalopathies/chemically induced/therapyMyelin Basic Protein/metabolismNerve Tissue Proteins/metabolismNeuroglia/drug effects/physiologyNeurons/drug effects/metabolismNeuroprotective Agents/pharmacology/therapeutic useOligodendrocyte Transcription Factor 2Plant Lectins/metabolismRatsRats, Sprague-Dawley
Identifiers
PMID: 27222132
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Article (Published version) (1.9 MB) - document accessible for UNIGE members only Limited access to UNIGE
Structures
Research group Prévention des complications néonatales d'origine périnatale (990)
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PANSIOT, Julien et al. Glial response to 17β-estradiol in neonatal rats with excitotoxic brain injury. In: Experimental Neurology, 2016, vol. 282, p. 56-65. https://archive-ouverte.unige.ch/unige:104563

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Deposited on : 2018-05-18

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