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Title

Sildenafil, a cyclic GMP phosphodiesterase inhibitor, induces microglial modulation after focal ischemia in the neonatal mouse brain

Authors
Moretti, Raffaella
Leger, Pierre-Louis
Besson, Valérie C
Csaba, Zsolt
Pansiot, Julien
Di Criscio, Lorena
Gentili, Andrea
Titomanlio, Luigi
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Published in Journal of Neuroinflammation. 2016, vol. 13, no. 1, p. 95
Abstract Perinatal ischemic stroke is the most frequent form of cerebral infarction in neonates; however, evidence-based treatments are currently lacking. We have previously demonstrated a beneficial effect of sildenafil citrate, a PDE-5 inhibitor, on stroke lesion size in neonatal rat pups. The present study investigated the effects of sildenafil in a neonatal mouse stroke model on (1) hemodynamic changes and (2) regulation of astrocyte/microglia-mediated neuroinflammation.
Keywords AnimalsAnimals, NewbornBrain Ischemia/enzymology/pathologyDisease Models, AnimalImmunohistochemistryMiceMice, Inbred C57BLMicroglia/drug effects/enzymologyPhosphodiesterase Inhibitors/pharmacologyPolymerase Chain ReactionSildenafil Citrate/pharmacology
Identifiers
PMID: 27126393
Full text
Article (Published version) (5.2 MB) - public document Free access
Structures
Research group Prévention des complications néonatales d'origine périnatale (990)
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MORETTI, Raffaella et al. Sildenafil, a cyclic GMP phosphodiesterase inhibitor, induces microglial modulation after focal ischemia in the neonatal mouse brain. In: Journal of Neuroinflammation, 2016, vol. 13, n° 1, p. 95. https://archive-ouverte.unige.ch/unige:104562

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Deposited on : 2018-05-18

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