Scientific article
English

Effect of early low-dose hydrocortisone on survival without bronchopulmonary dysplasia in extremely preterm infants (PREMILOC): a double-blind, placebo-controlled, multicentre, randomised trial

Published inThe Lancet, vol. 387, no. 10030, p. 1827-1836
Publication date2016
Abstract

Bronchopulmonary dysplasia, a major complication of extreme prematurity, has few treatment options. Postnatal steroid use is controversial, but low-dose hydrocortisone might prevent the harmful effects of inflammation on the developing lung. In this study, we aimed to assess whether low-dose hydrocortisone improved survival without bronchopulmonary dysplasia in extremely preterm infants.

Keywords
  • Anti-Inflammatory Agents/administration & dosage
  • Bronchopulmonary Dysplasia/prevention & control
  • Double-Blind Method
  • Female
  • France
  • Humans
  • Hydrocortisone/administration & dosage/analogs & derivatives
  • Infant, Extremely Premature
  • Infant, Newborn
  • Logistic Models
  • Male
  • Treatment Outcome
Affiliation entities Not a UNIGE publication
Citation (ISO format)
BAUD, Olivier et al. Effect of early low-dose hydrocortisone on survival without bronchopulmonary dysplasia in extremely preterm infants (PREMILOC): a double-blind, placebo-controlled, multicentre, randomised trial. In: The Lancet, 2016, vol. 387, n° 10030, p. 1827–1836. doi: 10.1016/S0140-6736(16)00202-6
Main files (1)
Article (Published version)
accessLevelRestricted
Identifiers
Journal ISSN0140-6736
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2downloads

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