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Scientific article
English

Early Recruitment of Cerebral Microcirculation by Neuronal Nitric Oxide Synthase Inhibition in a Juvenile Ischemic Rat Model

ContributorsLeger, P L; Bonnin, P; Moretti, R; Tanaka, S; Duranteau, J; Renolleau, S; Baud, Olivier; Charriaut-Marlangue, C
Published inCerebrovascular Diseases, vol. 41, no. 1-2, p. 40-49
Publication date2016
Abstract

The development of collateral circulation is proposed as an inherent compensatory mechanism to restore impaired blood perfusion after ischemia, at least in the penumbra. We have studied the dynamic macro- and microcirculation after ischemia-reperfusion in the juvenile rat brain and evaluated the impact of neuronal nitric oxide synthase (nNOS) inhibition on the collateral flow.

Keywords
  • Animals
  • Blood Flow Velocity/drug effects
  • Brain/blood supply/drug effects
  • Brain Ischemia
  • Cerebral Angiography
  • Cerebrovascular Circulation/drug effects
  • Collateral Circulation/drug effects
  • Enzyme Inhibitors/pharmacology
  • Hemodynamics/drug effects
  • Indazoles/pharmacology
  • Microcirculation/drug effects
  • Nitric Oxide Synthase Type I/antagonists & inhibitors
  • Rats
  • Reperfusion
Affiliation entities
Research groups
Citation (ISO format)
LEGER, P L et al. Early Recruitment of Cerebral Microcirculation by Neuronal Nitric Oxide Synthase Inhibition in a Juvenile Ischemic Rat Model. In: Cerebrovascular Diseases, 2016, vol. 41, n° 1-2, p. 40–49. doi: 10.1159/000441663
Identifiers
Journal ISSN1015-9770
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Creation17/05/2018 15:33:00
First validation17/05/2018 15:33:00
Update15/03/2023 08:13:36
Status update15/03/2023 08:13:36
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