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Title

Early Recruitment of Cerebral Microcirculation by Neuronal Nitric Oxide Synthase Inhibition in a Juvenile Ischemic Rat Model

Authors
Leger, P L
Bonnin, P
Moretti, R
Tanaka, S
Duranteau, J
Renolleau, S
Charriaut-Marlangue, C
Published in Cerebrovascular Diseases. 2016, vol. 41, no. 1-2, p. 40-49
Abstract The development of collateral circulation is proposed as an inherent compensatory mechanism to restore impaired blood perfusion after ischemia, at least in the penumbra. We have studied the dynamic macro- and microcirculation after ischemia-reperfusion in the juvenile rat brain and evaluated the impact of neuronal nitric oxide synthase (nNOS) inhibition on the collateral flow.
Keywords AnimalsBlood Flow Velocity/drug effectsBrain/blood supply/drug effectsBrain IschemiaCerebral AngiographyCerebrovascular Circulation/drug effectsCollateral Circulation/drug effectsEnzyme Inhibitors/pharmacologyHemodynamics/drug effectsIndazoles/pharmacologyMicrocirculation/drug effectsNitric Oxide Synthase Type I/antagonists & inhibitorsRatsReperfusion
Identifiers
PMID: 26599266
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Structures
Research group Prévention des complications néonatales d'origine périnatale (990)
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(ISO format)
LEGER, P L et al. Early Recruitment of Cerebral Microcirculation by Neuronal Nitric Oxide Synthase Inhibition in a Juvenile Ischemic Rat Model. In: Cerebrovascular Diseases, 2016, vol. 41, n° 1-2, p. 40-49. https://archive-ouverte.unige.ch/unige:104559

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Deposited on : 2018-05-18

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