Early Recruitment of Cerebral Microcirculation by Neuronal Nitric Oxide Synthase Inhibition in a Juvenile Ischemic Rat Model
|Published in||Cerebrovascular Diseases. 2016, vol. 41, no. 1-2, p. 40-49|
|Abstract||The development of collateral circulation is proposed as an inherent compensatory mechanism to restore impaired blood perfusion after ischemia, at least in the penumbra. We have studied the dynamic macro- and microcirculation after ischemia-reperfusion in the juvenile rat brain and evaluated the impact of neuronal nitric oxide synthase (nNOS) inhibition on the collateral flow.|
|Keywords||Animals — Blood Flow Velocity/drug effects — Brain/blood supply/drug effects — Brain Ischemia — Cerebral Angiography — Cerebrovascular Circulation/drug effects — Collateral Circulation/drug effects — Enzyme Inhibitors/pharmacology — Hemodynamics/drug effects — Indazoles/pharmacology — Microcirculation/drug effects — Nitric Oxide Synthase Type I/antagonists & inhibitors — Rats — Reperfusion|
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|Research group||Prévention des complications néonatales d'origine périnatale (990)|
|LEGER, P L et al. Early Recruitment of Cerebral Microcirculation by Neuronal Nitric Oxide Synthase Inhibition in a Juvenile Ischemic Rat Model. In: Cerebrovascular Diseases, 2016, vol. 41, n° 1-2, p. 40-49. doi: 10.1159/000441663 https://archive-ouverte.unige.ch/unige:104559|