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Impact of inhaled nitric oxide on white matter damage in growth-restricted neonatal rats

Pham, Hoa
Duy, An Phan
Pansiot, Julien
Bollen, Bieke
Gallego, Jorge
Charriaut-Marlangue, Christiane
Published in Pediatric Research. 2015, vol. 77, no. 4, p. 563-569
Abstract Fetal growth restriction is the second leading cause of perinatal morbidity and mortality, and neonates with intrauterine growth retardation (IUGR) have increased neurocognitive and neuropsychiatric morbidity. These neurocognitive impairments are mainly related to injury of the developing brain associated with IUGR. Growing evidence from preclinical models of brain injury in both adult and neonatal rodents supports the view that nitric oxide can promote neuroprotection.
Keywords Administration, InhalationAnimalsAnimals, NewbornAxons/pathologyBehavior, AnimalBrain Injuries/pathology/prevention & controlCognition Disorders/physiopathologyDisease Models, AnimalFemaleFetal Growth RetardationHypoxiaImmunohistochemistryLearningMyelin Sheath/chemistryNeuroprotective Agents/chemistryNitric Oxide/administration & dosageOligodendroglia/metabolismPregnancyRatsRats, Sprague-DawleyWhite Matter/drug effects/pathology
PMID: 25580736
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Research group Prévention des complications néonatales d'origine périnatale (990)
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PHAM, Hoa et al. Impact of inhaled nitric oxide on white matter damage in growth-restricted neonatal rats. In: Pediatric Research, 2015, vol. 77, n° 4, p. 563-569. doi: 10.1038/pr.2015.4 https://archive-ouverte.unige.ch/unige:104552

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Deposited on : 2018-05-18

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