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Controlled arterial reflow after ischemia induces better outcomes in the juvenile rat brain

Bonnin, Philippe
Pansiot, Julien
Paven, Elise
Eloi, Maxime
Renolleau, Sylvain
Leger, Pierre-Louis
Charriaut-Marlangue, Christiane
Published in Journal of Cerebral Blood Flow and Metabolism. 2017, vol. 37, no. 9, p. 3091-3096
Abstract Our objective was to determine whether controlled reflow on one side and/or the other side after bilateral carotid occlusion release could reduce cell death in focal ischemic P14 rats. Arterial blood flow was measured using ultrasonography. Cell death, inflammation and nitrotyrosine were measured using immunofluorescence. When reflow was first induced in the contralateral side, we observed improved outcome markers compared with those when reflow was first induced in the ipsilateral side and/or simultaneous reflow was induced in both sides. Our data suggest that progressive rerouting of arterial flow through the circle of Willis toward the ischemic site reduced cell death.
Keywords AnimalsBrain Ischemia/diagnostic imaging/pathology/physiopathology/therapyCell DeathCerebral Arteries/pathology/physiopathologyCerebrovascular Circulation/physiologyCyclooxygenase 2/geneticsDisease Models, AnimalProstaglandin-E Synthases/geneticsRats, WistarReperfusion/methodsReperfusion Injury/diagnostic imaging/metabolism/pathology/physiopathologyTreatment OutcomeTyrosine/analogs & derivatives/biosynthesisUltrasonography
PMID: 28695754
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Research group Prévention des complications néonatales d'origine périnatale (990)
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BONNIN, Philippe et al. Controlled arterial reflow after ischemia induces better outcomes in the juvenile rat brain. In: Journal of Cerebral Blood Flow and Metabolism, 2017, vol. 37, n° 9, p. 3091-3096. doi: 10.1177/0271678X17719614 https://archive-ouverte.unige.ch/unige:104541

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Deposited on : 2018-05-17

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