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Cysteine-reactive probes and their use in chemical proteomics

Published in Chemical Communications. 2018, vol. 54, no. 36, p. 4501-4512
Abstract Proteomic profiling using bioorthogonal chemical probes that selectively react with certain amino acids is now a widely used method in life sciences to investigate enzymatic activities, study posttranslational modifications and discover novel covalent inhibitors. Over the past two decades, researchers have developed selective probes for several different amino acids, including lysine, serine, cysteine, threonine, tyrosine, aspartate and glutamate. Among these amino acids, cysteines are particularly interesting due to their highly diverse and complex biochemical role in our cells. In this feature article, we focus on the chemical probes and methods used to study cysteines in complex proteomes.
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Research group Groupe Adibekian
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HOCH, Dominic Gregor, ABEGG, Daniel, ADIBEKIAN, Alexander. Cysteine-reactive probes and their use in chemical proteomics. In: Chemical Communications, 2018, vol. 54, n° 36, p. 4501-4512. doi: 10.1039/C8CC01485J https://archive-ouverte.unige.ch/unige:104188

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Deposited on : 2018-05-08

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