en
Scientific article
English

Electrophysiological evidence for oxytocin receptors on neurones located in the dorsal motor nucleus of the vagus nerve in the rat brainstem

Published inJournal of receptor research, vol. 8, no. 1-4, p. 273-282
Publication date1988
Abstract

Intracellular recordings were obtained from vagal neurones and their response to oxytocin was investigated in slices from the rat brainstem. Following recording, Lucifer Yellow was injected into the cells in order to verify their localization within the dorsal motor nucleus of the vagus nerve. Virtually all neurones throughout the rostro-caudal extent of the nucleus increased their rate of firing in the presence of 10-1000 nM oxytocin and their membrane depolarized in a reversible, concentration-dependent manner. This excitation was probably exerted directly on the impaled cells rather than being synaptically mediated, since it persisted in a low calcium-high magnesium medium or in the presence of tetrodotoxin. These data provide evidence for a direct membrane effect of oxytocin on a defined population of neurones in the rat brain.

Keywords
  • Action Potentials/drug effects
  • Animals
  • Arginine Vasopressin/metabolism/pharmacology
  • Brain Stem/ analysis
  • Isoquinolines
  • Male
  • Neurons/analysis/drug effects
  • Oxytocin/ metabolism/pharmacology
  • Rats
  • Rats, Inbred Strains
  • Receptors, Angiotensin/ analysis
  • Receptors, Oxytocin
  • Tetrodotoxin/pharmacology
  • Vagus Nerve/ analysis
Citation (ISO format)
RAGGENBASS, Mario et al. Electrophysiological evidence for oxytocin receptors on neurones located in the dorsal motor nucleus of the vagus nerve in the rat brainstem. In: Journal of receptor research, 1988, vol. 8, n° 1-4, p. 273–282.
Main files (1)
Article
accessLevelRestricted
Identifiers
ISSN of the journal0197-5110
513views
0downloads

Technical informations

Creation08/06/2010 1:47:30 PM
First validation08/06/2010 1:47:30 PM
Update time03/14/2023 3:59:15 PM
Status update03/14/2023 3:59:15 PM
Last indexation02/12/2024 7:06:12 PM
All rights reserved by Archive ouverte UNIGE and the University of GenevaunigeBlack