Doctoral thesis

Directional reaching for water: a novel cortex dependent forelimb behavior in mice

ContributorsBonardi, Claudia
DirectorsHuber, Danielorcid
Defense date2018-02-05

Reaching for objects is a fundamental component of most of our actions, yet the underlying neuronal circuits remain poorly understood. To dissect the neuronal dynamics of reaching movements a wide range of molecular, optogenetic and optical imaging tools are necessary. These tools are available in rodent research where robust behavioral paradigms are lacking. Current reaching tasks in rodents have key limitations: low number of trials per session (<50), manual reward delivery and unidirectional target presentation. This thesis describes a multi-directional reaching task that overcomes these limitations by automating the training and replacing food with water rewards. Head-restrained mice rapidly learned to locate water droplets and reach for them hundreds of times per session. Interestingly, a chemosensory system was used for target localization instead of the expected whisker system. Cortical inactivation and two photon imaging experiments revealed the key role of motor cortex in both reaching movement execution and direction selectivity.

  • Motor cortex
  • Reaching
  • Behavior
  • Mice
  • Optogenetics
  • Task
  • Forelimb
  • Movement
  • Brain
  • Voluntary
  • Skilled
  • Execution
NoteDiplôme commun des univ. de Genève et Lausanne. Thèse en Neurosciences des universités de Genève et de Lausanne
  • Autre - New York Stem Cell Foundation
  • Autre - Fondation pour des bourses d'études italo-suisses
Citation (ISO format)
BONARDI, Claudia. Directional reaching for water: a novel cortex dependent forelimb behavior in mice. 2018. doi: 10.13097/archive-ouverte/unige:103945
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Technical informations

Creation04/26/2018 10:46:00 AM
First validation04/26/2018 10:46:00 AM
Update time03/15/2023 8:11:03 AM
Status update03/15/2023 8:11:02 AM
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