Neuro-imaging and electrophysiology findings have increasingly established that epileptic activity is related to abnormal function within a network of cortical and subcortical brain structures (epileptic network) [18] as reflected in the new ILAE classification [20]. The estimation of connectivity and analysis of the related networks (connectomics, graph analysis) represent a fast growing field in clinical and basic neuroscience [12]. This brief non-extensive review highlights the growing clinical implications of recent studies mapping epileptic network connectivity from non-invasive measurements.