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Article scientifique
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Reduced amygdala activity during aversive conditioning in human narcolepsy

Publié dansAnnals of neurology, vol. 67, no. 3, p. 394-398
Date de publication2010
Résumé

Narcolepsy with cataplexy is a sleep-wake disorder caused by a loss of hypothalamic hypocretins. Here we assessed the time course of amygdala activation during aversive conditioning in unmedicated patients with narcolepsy. Unlike healthy matched control subjects, narcolepsy patients had no enhancement of amygdala response to conditioned stimuli and no increase in functional coupling between the amygdala and medial prefrontal cortex. These findings suggest that human narcolepsy is accompanied by abnormal emotional learning, and that, in line with animal data, the hypocretin system and the amygdala are involved in this process.

Mots-clés
  • Adult
  • Affective Symptoms/etiology/physiopathology
  • Amygdala/*physiopathology
  • Attention/physiology
  • Avoidance Learning/*physiology
  • Biological Markers/analysis/blood
  • Brain Mapping
  • Conditioning (Psychology)/*physiology
  • Emotions/physiology
  • Fear/physiology
  • Female
  • Humans
  • Intracellular Signaling Peptides and Proteins/analysis/blood
  • Learning Disorders/etiology/*physiopathology
  • Magnetic Resonance Imaging
  • Male
  • Middle Aged
  • Narcolepsy/complications/*physiopathology/*psychology
  • Neuropeptides/analysis/blood
  • Neuropsychological Tests
  • Photic Stimulation
  • Reaction Time/physiology
  • Young Adult
Citation (format ISO)
PONZ, Aurelie et al. Reduced amygdala activity during aversive conditioning in human narcolepsy. In: Annals of neurology, 2010, vol. 67, n° 3, p. 394–398.
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Article
accessLevelRestricted
Identifiants
ISSN du journal0364-5134
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Informations techniques

Création06/08/2010 13:47:23
Première validation06/08/2010 13:47:23
Heure de mise à jour14/03/2023 15:59:10
Changement de statut14/03/2023 15:59:10
Dernière indexation12/02/2024 19:05:42
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