en
Scientific article
English

Pre-frontal-insular-cerebellar modifications correlate with disgust feeling blunting after subthalamic stimulation: A positron emission tomography study in Parkinson's disease

Published inJournal of Neuropsychology, vol. 11, no. 3, p. 378-395
Publication date2017
Abstract

Subthalamic nucleus (STN) deep brain stimulation (DBS) has recently advanced our understanding of the major role played by this basal ganglion in human emotion. Research indicates that STN DBS can induce modifications in all components of emotion, and neuroimaging studies have shown that the metabolic modifications correlated with these emotional disturbances following surgery are both task- and sensory input-dependent. Nevertheless, to date, these modifications have not been confirmed for all emotional components, notably subjective emotional experience, or feelings. To identify the neural network underlying the modification of feelings following STN DBS, we assessed 16 patients with Parkinson's disease before and after surgery, using both subjective assessments of emotional experience and 18[F]fluorodeoxyglucose positron emission tomography (18FDG-PET). The patients viewed six film excerpts intended to elicit happy, angry, fearful, sad, disgusted, and neutral feelings, and they selfrated the intensity of these feelings. After DBS, there was a significant reduction in the intensity of the disgust feeling. Correlations were observed between decreased disgust experience and cerebral glucose metabolism (FDG uptake) in the bilateral pre-frontal cortices (orbitofrontal, dorsolateral, and inferior frontal gyri), bilateral insula, and right cerebellum. We suggest that the STN contributes to the synchronization process underlying the emergence of feelings.

Citation (ISO format)
ORY, Sophie et al. Pre-frontal-insular-cerebellar modifications correlate with disgust feeling blunting after subthalamic stimulation: A positron emission tomography study in Parkinson’s disease. In: Journal of Neuropsychology, 2017, vol. 11, n° 3, p. 378–395. doi: 10.1111/jnp.12094
Main files (1)
Article (Published version)
accessLevelRestricted
Identifiers
ISSN of the journal1748-6645
396views
1downloads

Technical informations

Creation04/18/2018 10:02:00 AM
First validation04/18/2018 10:02:00 AM
Update time03/15/2023 8:09:28 AM
Status update03/15/2023 8:09:27 AM
Last indexation01/17/2024 2:43:25 AM
All rights reserved by Archive ouverte UNIGE and the University of GenevaunigeBlack