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Title

Pre-frontal-insular-cerebellar modifications correlate with disgust feeling blunting after subthalamic stimulation: A positron emission tomography study in Parkinson's disease

Authors
Ory, Sophie
Le Jeune, Florence
Haegelen, Claire
Vicente, Siobhan
Philippot, Pierre
Dondaine, Thibaut
Jannin, Pierre
Drapier, Sophie
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Published in Journal of Neuropsychology. 2017, vol. 11, no. 3, p. 378-395
Abstract Subthalamic nucleus (STN) deep brain stimulation (DBS) has recently advanced our understanding of the major role played by this basal ganglion in human emotion. Research indicates that STN DBS can induce modifications in all components of emotion, and neuroimaging studies have shown that the metabolic modifications correlated with these emotional disturbances following surgery are both task- and sensory input-dependent. Nevertheless, to date, these modifications have not been confirmed for all emotional components, notably subjective emotional experience, or feelings. To identify the neural network underlying the modification of feelings following STN DBS, we assessed 16 patients with Parkinson’s disease before and after surgery, using both subjective assessments of emotional experience and 18[F]fluorodeoxyglucose positron emission tomography (18FDG-PET). The patients viewed six film excerpts intended to elicit happy, angry, fearful, sad, disgusted, and neutral feelings, and they selfrated the intensity of these feelings. After DBS, there was a significant reduction in the intensity of the disgust feeling. Correlations were observed between decreased disgust experience and cerebral glucose metabolism (FDG uptake) in the bilateral pre-frontal cortices (orbitofrontal, dorsolateral, and inferior frontal gyri), bilateral insula, and right cerebellum. We suggest that the STN contributes to the synchronization process underlying the emergence of feelings.
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Structures
Research groups Affective sciences
Neuroscience de l'émotion et dynamiques affectives (NEAD)
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ORY, Sophie et al. Pre-frontal-insular-cerebellar modifications correlate with disgust feeling blunting after subthalamic stimulation: A positron emission tomography study in Parkinson's disease. In: Journal of Neuropsychology, 2017, vol. 11, n° 3, p. 378-395. https://archive-ouverte.unige.ch/unige:103802

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Deposited on : 2018-04-24

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